ArticleNature neuroscience2026
Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks.
Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Integrating AI with Biosensors and Voltammetry for Neurotransmitter Detection and Quantification: A Systematic Review.Biosensors · 2025Pooled it
- Anterior Cingulate Cortex Projections to the Amygdala in Primates: Topographic and Layer-Specific Organization Underlying Emotion and Mood Regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- DBS: from neuromodulation to neuroremodelling.Nature neuroscience · 2026Article
- Impact of Inflammation on White Matter Integrity and Functional Connectivity in Chronic Major Depressive Disorder.Biological psychiatry · 2026Article
- Review
- Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex.bioRxiv : the preprint server for biology · 2025Article
- Mesoscale brain-wide fluctuation analysis: revealing ketamine's rapid antidepressant across multiple brain regions.Translational psychiatry · 2025Article
- What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Intrinsic functional and structural network organization in the macaque insula.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A nonlinear relationship of evoked responses following charge-balanced single-pulse electrical stimulation with varying pulse widths.Brain stimulationArticle
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Deep brain stimulation (DBS) is an emerging therapy for treatment-resistant neurological and psychiatric disorders. Despite this, little is known about the anatomical and functional mechanisms that underlie this therapy. We targeted DBS to white matter adjacent to the subcallosal anterior cingulate cortex (SCC-DBS) in macaques, modeling the approach proven effective for depression in humans. SCC-DBS caused a selective increase in fractional anisotropy, linked to white matter microstructure, in the cingulum bundle. At the cellular level, this was associated with an increase in both myelinated oligodendrocytes and the degree of myelination in the mid-cingulum bundle. SCC-DBS also altered brain-wide functional connectivity, changing interactions between the SCC and multiple brain networks, most notably the default mode network that has been implicated in depression. Overall, our data indicate that white matter remodeling as well as selective changes in multiple brain networks may contribute to DBS's therapeutic efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.