ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
Dorsal raphe nucleus enkephalin peptide modulates behavioral preference.
Kathryn Braden, Andrew Trinagel, Eric Acevedo, Laura N Massó-Quiñones, Alexandra E Bernstein, Marcela Arguello, Aidan Evans-Strong, Samantha S Dunn, Daniel C Castro
Abstract read
In one paragraphArticle in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Eric AcevedoCollege of Arts and Sciences, Washington University School of Medicine, Saint Louis, MO, USA.
Laura N Massó-QuiñonesNeuroscience Postbaccalaureate Research Education Program (Neuroprep), Washington University School of Medicine, Saint Louis, MO, USA.
Alexandra E BernsteinDivision of Biology and Biomedical Sciences, Neuroscience Program, Washington University School of Medicine, Saint Louis, MO, USA.
Marcela ArguelloCollege of Arts and Sciences, Washington University School of Medicine, Saint Louis, MO, USA.
Aidan Evans-StrongDivision of Biology and Biomedical Sciences, Neuroscience Program, Washington University School of Medicine, Saint Louis, MO, USA.
Samantha S DunnDivision of Biology and Biomedical Sciences, Neuroscience Program, Washington University School of Medicine, Saint Louis, MO, USA.
Funding
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Irfan J Lodhi · 2013 to 2026
$27.1MNeuroscience Training Program at Washington UniversityT32NS121881 · NINDS · WASHINGTON UNIVERSITY · PI Martha W Bagnall, Daniel Kerschensteiner · 2021 to 2026
$3.1MInvestigating non-canonical mechanisms of endogenous opioids on motivation in dorsal midbrainR01MH132504 · NIMH · WASHINGTON UNIVERSITY · PI Daniel Charles Castro · 2023 to 2026
$2.1MThe WUSTL PREP post-bacc program to enhance doctoral readiness in neuroscienceR25NS130965 · NINDS · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner, Jose A Moron-Concepcion · 2023 to 2026
$1.4MPhysiological and Molecular Mechanisms of Mu Opioid Receptors in Motivation and AffectR00DA049862 · NIDA · WASHINGTON UNIVERSITY · PI CASTRO, DANIEL CHARLES · 2022 to 2024
$747kInvestigating the role of dorsal raphe nucleus enkephalin neurons in motivational and affective behaviors during chronic painF32DA062455 · NIDA · WASHINGTON UNIVERSITY · PI Kathryn I Braden · 2025 to 2026
$161kNIDA NIH HHS F32 DA062455NIDA NIH HHS R00 DA049862NIDDK NIH HHS P30 DK020579NIMH NIH HHS R01 MH132504NINDS NIH HHS R25 NS130965NINDS NIH HHS T32 NS121881U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH132504U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R25NS130965U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) T32NS121881U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) F32DA062455U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R00DA049862WUSTL | Washington University School of Medicine in St. Louis BioSURF ProgramWUSTL | Washington University School of Medicine in St. Louis SURGE program
6 · The paper itselfAbstract
The endogenous opioid system is a powerful modulator of motivation and affect. The dorsal raphe nucleus (DRN) in the midbrain has been established as an important site of opioid action and is an integral hub in behavioral modulation. To investigate the functional significance of DRN opioid signaling in aversive and appetitive behaviors we disrupted preproenkephalin (Penk) in DRN using CRISPR-Cas9 technology in Penk-Cre mice. We found that CRISPR mediated knockdown of enkephalin peptide in the DRN (DRN
Identifiers
PMID42225850
PMCPMC13456122
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