Evidence map›Paper›PMID 42225837›Full record

ArticleScientific reports2026

A pilot study in the swine model of lethal cyanide intoxication indicates efficacy of a platinum-methionine complex countermeasure.

Vallabh Suresh, Tara Hendry-Hofer, Matthew M Behymer, Anjali K Nath, Shuning Zheng, Naoaki Fujii, Brian A Logue, Ari S Arzumanian, Calum A MacRae, Randall Peterson and 3 more

Abstract read
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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vallabh SureshDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0000-0002-9904-3988
Tara Hendry-HoferDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, USA.ORCID http://orcid.org/0000-0002-0576-753X
Matthew M BehymerDepartment of Industrial and Molecular Pharmaceutics, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0000-0002-5856-6360
Anjali K NathDepartment of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.ORCID https://orcid.org/0000-0002-5032-7250
Shuning ZhengDepartment of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.ORCID https://orcid.org/0000-0002-6479-4490
Naoaki FujiiDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0000-0002-2528-6944
Brian A LogueDepartment of Chemistry and Biochemistry, South Dakota State University, Brookings, SD, 57007, USA.ORCID http://orcid.org/0000-0002-2400-9339
Ari S ArzumanianDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN, 47907, USA.
Calum A MacRaeDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.ORCID https://orcid.org/0000-0001-5181-2664
Randall PetersonDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, 84112, USA.ORCID http://orcid.org/0000-0003-0727-3469
Gregory T KnippDepartment of Industrial and Molecular Pharmaceutics, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN, 47907, USA.ORCID https://orcid.org/0000-0002-4199-2929
Vikhyat S BebartaDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, USA.ORCID https://orcid.org/0000-0001-8816-1199
Vincent Jo DavissonDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN, 47907, USA. davisson@purdue.edu.ORCID http://orcid.org/0000-0003-1182-0007

Funding

Training & Education CoreU54NS112107 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI GERSZTEN, ROBERT E · 2019 to 2023
$16.0M
NIH HHS U54NS112107NINDS NIH HHS U54 NS112107U.S. Department of Education P200A150136
6 · The paper itself

Abstract

Cyanide presents a chemical security threat because of its wide availability, due to industrial uses, and significant toxicity. Platinum-thioether complexes are a recent addition to candidate antidotes, showing efficacy in mouse models of hydrogen cyanide inhalation and reversing toxicity measures in rabbits. This pilot study evaluated the effectiveness of a platinum-methionine complex (Met2Pt), a potent lead candidate, in a lethal swine model, which provides a solid foundation for future research. Potassium cyanide (0.2 mg/kg/min; IV) was infused into anesthetized swine until 6 min post-apnea. Met2Pt (2.9 mg Pt/kg in 3 mL) or 100 mM phosphate buffer vehicle (3 mL) were then administered intravenously (IV) or intramuscularly (IM). Vital signs, metabolites, and pharmacokinetics were monitored for > 90 min. IV Met2Pt was highly efficacious compared to all other treatments, rescuing all swine in the group and reversing cyanide-derangements in lactate concentration (Welch One-Way ANOVA, p < 10

Indexed as

AntidotesCyanidesMethioninePlatinumAnimalsDisease Models, AnimalFemalePilot ProjectsPotassium CyanideSwineAntidotesCyanidesMethioninePlatinumPotassium CyanideAntidoteCyanide poisoningMedical countermeasuresPlatinum compoundsPreclinical large animal modelSwine

Identifiers

PMID42225837
PMCPMC13458706

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.