Evidence map›Paper›PMID 42225783›Full record

ArticleScientific reports2026

Reliability of quantitative and qualitative chorioretinal uveitis lesion analysis on blue, green, and near-infrared fundus autofluorescence and color fundus photography.

Marie D Just, Jana Koch, Gabriela Guzman, Lennart J Overbeck, Moritz Berger, Jan H Terheyden, Selina Foti, Matthias Schmid, Frank G Holz, Marlene Saßmannshausen and 3 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marie D Just *Department of Ophthalmology, University Hospital Bonn, University of Bonn, Ernst-Abbe-Straße 2, 53127, Bonn, Germany.
Jana Koch *Department of Ophthalmology, University Hospital Bonn, University of Bonn, Ernst-Abbe-Straße 2, 53127, Bonn, Germany.
Gabriela GuzmanDepartment of Ophthalmology, University Hospital Bonn, University of Bonn, Ernst-Abbe-Straße 2, 53127, Bonn, Germany.
Lennart J OverbeckDepartment of Ophthalmology, University Hospital Bonn, University of Bonn, Ernst-Abbe-Straße 2, 53127, Bonn, Germany.
Moritz BergerDepartment of Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Bonn, Germany.
Jan H TerheydenDepartment of Ophthalmology, University Hospital Bonn, University of Bonn, Ernst-Abbe-Straße 2, 53127, Bonn, Germany.
Selina FotiDepartment of Ophthalmology, University Hospital Bonn, University of Bonn, Ernst-Abbe-Straße 2, 53127, Bonn, Germany.
Matthias SchmidDepartment of Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Bonn, Germany.
Frank G HolzDepartment of Ophthalmology, University Hospital Bonn, University of Bonn, Ernst-Abbe-Straße 2, 53127, Bonn, Germany.
Marlene SaßmannshausenDepartment of Ophthalmology, University Hospital Bonn, University of Bonn, Ernst-Abbe-Straße 2, 53127, Bonn, Germany.
Matthias M MauschitzDepartment of Ophthalmology, University Hospital Bonn, University of Bonn, Ernst-Abbe-Straße 2, 53127, Bonn, Germany.
Robert P FingerDepartment of Ophthalmology, University Hospital Bonn, University of Bonn, Ernst-Abbe-Straße 2, 53127, Bonn, Germany.
Maximilian W M WintergerstDepartment of Ophthalmology, University Hospital Bonn, University of Bonn, Ernst-Abbe-Straße 2, 53127, Bonn, Germany. maximilian.wintergerst@ukbonn.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As there is a lack of reliable structural outcome parameters for posterior uveitis trials, we compared inter-rater reliability (IRR) of chorioretinal lesion area measurement (quantitative analyses) and characterization (qualitative analyses) on color fundus photography (CFP) and multimodal fundus autofluorescence (FAF). In this prospective cohort study, posterior uveitis eyes were imaged with CFP (Eidon, iCare, Vantaa), short- (swBAF, 450 nm; Eidon) and long-wavelength blue-light-autofluorescence (lwBAF, 488 nm), green-light-autofluorescence (GAF, 518 nm), and infrared-autofluorescence (IRAF, 787 nm) (all Spectralis, Heidelberg Engineering, Heidelberg). Lesion area, measured with ImageJ (National Institutes of Health), and image characteristics of lesions were graded on all modalities by two masked raters. A total of 318 lesions from 27 eyes (17 patients) were included. Absolute inter-rater differences in area measurement were 0.57, 0.78, 0.30, 0.36, and 0.55 in standardized 10

Indexed as

Fluorescein AngiographyOptical ImagingUveitis, PosteriorAdultBlue LightFemaleFundus OculiGreen LightHumansMaleMiddle AgedPhotographyProspective StudiesReproducibility of ResultsColor fundus photographyEndpointFundus autofluorescenceInter-rater reliabilityPosterior uveitisQuantitative imaging biomarkers

Identifiers

PMID42225783
PMCPMC13226665

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