Evidence map›Paper›PMID 42225631›Full record

ArticleNature communications2026

An implantable mechano-electro cascade platform synchronizes neuro-muscle repair.

Liping Nan, Wentao Cao, Jiaqi Fang, Pengzhi Shi, Xuehan Jin, Jianguang Wang, Fengshan Jin, Feng Wang, Kaihang Song, Shengfu Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Liping Nan *Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, PR China.
Wentao Cao *Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Department of Prosthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, PR China. wt_cao@fudan.edu.cn.
Jiaqi Fang *Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, PR China.ORCID http://orcid.org/0009-0001-9565-2575
Pengzhi Shi *Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, PR China.
Xuehan JinDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, PR China.
Jianguang WangDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, PR China.
Fengshan JinDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital; Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, School of Medicine, Tongji University, Shanghai, PR China.
Feng WangDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, PR China.
Kaihang SongDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, PR China.
Shengfu LiuDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, PR China.
Zifei ZhouDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, PR China.
Xu WangDepartment of Orthopaedics, National Center for Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Tianlong WangDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, PR China.
Feng ChenShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Department of Prosthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, PR China. chen_feng@fudan.edu.cn.ORCID http://orcid.org/0000-0002-1162-1684
Junjian LiuDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, PR China. jjliu@tongji.edu.cn.
Yun QianDepartment of Orthopaedics, National Center for Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. sakio@sjtu.edu.cn.ORCID http://orcid.org/0000-0003-1600-5693

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral nerve injury triggers slow axonal regeneration and irreversible muscle atrophy due to the absence of synchronous neuromuscular repair strategies. We present a fully implantable, self-powered Mechano-driven Electro-adaptable Bioelectronic Implant System (MEBIS) enabling coordinated mechanical-electrical stimulation for integrated neuromuscular regeneration. A programmable robotic actuator delivers quantifiable mechanical massage to denervated muscle, enhancing perfusion while deforming a nanogenerator that converts motion into localized electrical cues. These signals stimulate injured nerves, inducing intracellular Ca

Indexed as

Muscle, SkeletalNerve RegenerationPeripheral Nerve InjuriesAnimalsAxonsElectric StimulationFemaleProstheses and ImplantsRatsRats, Sprague-DawleyRoboticsSchwann CellsSwine

Identifiers

PMID42225631
PMCPMC13392114

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.