Evidence map›Paper›PMID 42225629›Full record

ArticleCell death & disease2026

Deficient autophagy in retinal ganglion cells impairs the degradation of intracellular organelles, leading to neurodegeneration.

Yogapriya Sundaresan, Prabhavathi Maddineni, Sarahi Rios Arguello, Balasankara Reddy Kaipa, Justin Dinh Tran, Linya Li, Bindu Kodati, Gulab S Zode

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yogapriya Sundaresan *Gavin Herbert Eye Institute- Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California, Irvine, CA, USA.
Prabhavathi Maddineni *Department of Ophthalmology, School of Medicine, University of Missouri, Columbia, MO, USA.
Sarahi Rios ArguelloGavin Herbert Eye Institute- Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California, Irvine, CA, USA.
Balasankara Reddy KaipaGavin Herbert Eye Institute- Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California, Irvine, CA, USA.
Justin Dinh TranGavin Herbert Eye Institute- Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California, Irvine, CA, USA.
Linya LiGavin Herbert Eye Institute- Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California, Irvine, CA, USA.
Bindu KodatiDepartment of Pharmacology and Neuroscience, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA.
Gulab S ZodeGavin Herbert Eye Institute- Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California, Irvine, CA, USA. gzode@hs.uci.edu.ORCID http://orcid.org/0009-0005-9472-9373

Funding

Crosstalk Between Unfolded Protein Response and Autophagy for the Treatment of GlaucomaR01EY026177 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ZODE, GULAB · 2016 to 2025
$3.8M
Novel Genome Editing for the Treatment of GlaucomaR01EY030366 · NEI · UNIVERSITY OF IOWA · PI CLARK, ABBOT FREDERICK, SHEFFIELD, VAL C. · 2019 to 2023
$2.7M
Impaired TRVP4-eNOS signaling in TM contributes to glaucomaR01EY034238 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Swapnil K. Sonkusare, Gulab Zode · 2022 to 2026
$2.2M
Targeting ER Stress Pathway Using Sodium 4-Phenylbutyrate for the Treatment of POAGR01EY028616 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ZODE, GULAB · 2018 to 2021
$1.4M
The role of impaired mitophagy and mitochondrial dysfunction in glaucomatous neurodegenerationR00EY032982 · NEI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Prabhavathi Maddineni · 2024 to 2026
$758k
The role of impaired mitophagy and mitochondrial dysfunction in glaucomatous neurodegenerationK99EY032982 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI MADDINENI, PRABHAVATHI · 2021 to 2022
$199k
BrightFocus Foundation (BrightFocus) G2022004FFoundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) EY026177Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) EY028616Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) EY030366NEI NIH HHS K99 EY032982NEI NIH HHS R00 EY032982NEI NIH HHS R01 EY026177NEI NIH HHS R01 EY028616NEI NIH HHS R01 EY030366NEI NIH HHS R01 EY034238
6 · The paper itself

Abstract

Autophagy is a fundamental catabolic process that facilitates the degradation and recycling of cellular components like protein aggregates and defective organelles. However, the precise role of constitutive autophagy in regulating retinal ganglion cell (RGC) function and survival remains largely undefined. Here, we demonstrate that RGCs exhibit a robust and highly active constitutive autophagy. Furthermore, the selective autophagy knockout in RGCs induces neurodegeneration in Atg7

Indexed as

AutophagyNerve DegenerationOrganellesRetinal Ganglion CellsAnimalsAutophagosomesAutophagy-Related Protein 5Autophagy-Related Protein 7MiceMice, KnockoutMitochondriaOptic NerveAtg5 protein, mouseAutophagy-Related Protein 5Autophagy-Related Protein 7

Identifiers

PMID42225629
PMCPMC13434108

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.