Evidence map›Paper›PMID 42225628›Full record

ArticleNature communications2026

Compliance modulation of a soft robotic atrioventricular model of heart failure with preserved ejection fraction.

James Davies, Bibhu Sharma, Adrienne Ji, Gabriel Matus Vasquez, Chi Cong Nguyen, Emanuele Nicotra, Kefan Zhu, Phuoc Thien Phan, Jingjing Wan, Jelena Rnjak-Kovacina and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

James DaviesSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0001-7987-2378
Bibhu SharmaSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia.
Adrienne JiSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia.
Gabriel Matus VasquezSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia.
Chi Cong NguyenSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0002-8113-5163
Emanuele NicotraSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia.
Kefan ZhuSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia.
Phuoc Thien PhanSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia.
Jingjing WanSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia.
Jelena Rnjak-KovacinaSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0001-6121-4676
Michael StevensSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0003-3583-688X
Hoang-Phuong PhanSchool of Mechanical and Manufacturing Engineering, Faculty of Engineering, UNSW Sydney, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0002-1724-5667
Christopher HaywardDepartment of Cardiology, St Vincent's Hospital, Sydney, NSW, 2010, Australia.
Nigel Hamilton LovellSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0003-1637-1079
Thanh Nho DoSchool of Biomedical Engineering, Faculty of Engineering, UNSW, Sydney, NSW, 2052, Australia. tn.do@unsw.edu.au.ORCID http://orcid.org/0000-0002-4980-5251

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a common yet highly complex form of heart failure (HF). A major challenge in obtaining market approval for medical devices targeting HFpEF treatment is the absence of highly controllable testing models. This work introduces an in-vitro, biomimetic, left-heart, atrioventricular simulator, with a closed-loop control system designed to model HFpEF disease progression. While at proof-of-concept stage, its unique capabilities show promise for higher-dimensional modeling than existing models. The simulator employs artificial muscle fibers which are highly controllable on their relaxation stroke. Its goal-oriented control system enables compliance modulation of the artificial myocardium during diastole. By setting hemodynamic targets, the myocardium dynamically responds, replicating the biomechanics of HFpEF progression. The model effectively recreates key hallmarks of HFpEF phenotypes, including impaired relaxation, pericardial restraint, and increased ventricular stiffness, capturing both hemodynamic and biomechanic aspects of the disease. Its capability is further validated, simulating mechanical circulatory support for HFpEF treatment. While more work is needed to demonstrate clinical application through control system development, actuation speed improvements, and further clinical validation, this work shows promise as a powerful tool for device development and pathophysiological studies, advancing our understanding and treatment of heart diseases.

Indexed as

Heart FailureModels, CardiovascularRoboticsStroke VolumeBiomechanical PhenomenaHeart VentriclesHemodynamicsHumans

Identifiers

PMID42225628
PMCPMC13392148

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.