ArticleJournal of veterinary science2026
Behavioral characterization of olfactory, auditory, and motor deficits in 5×FAD mice.
Article in Journal of veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
importanceThe 5×FAD transgenic mouse model is widely used in Alzheimer's disease (AD) research, yet its non-cognitive phenotypes -- particularly motor coordination, olfactory sensitivity, and auditory reactivity -- remain poorly characterized across the full disease trajectory. Defining these sensory and sensorimotor deficits may enhance the translational relevance of this model and provide insight into non-cognitive features in preclinical AD studies.
objectiveTo characterize age-related motor, olfactory, and auditory changes in 5×FAD mice and assess associated AD pathologies and neuroinflammation in relevant brain regions.
methods5×FAD and control mice were tested at 3, 6, and 12 months. Locomotor activity and motor coordination were assessed using the open field and rotarod tests, respectively. Olfactory and auditory performance were evaluated using the buried food test and the acoustic startle response test, respectively. Amyloid-β pathology and glial activation were examined in relevant nervous system components using western blot and immunohistochemistry analyses.
results5×FAD mice showed no differences in open-field locomotion at any age, but exhibited a significantly greater passive clinging duration at 12 months compared to wild-type controls ( CONCLUSIONS AND RELEVANCE: This study provides an age-related behavioral and pathological characterization of olfactory and auditory impairments in the 5×FAD mouse model, with motor measures included as complementary assessments. Our findings broaden the spectrum of functional deficits associated with the AD pathology in this model.
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