Evidence map›Paper›PMID 42225601›Full record

ArticleJournal of veterinary science2026

Trivalent fowl adenovirus vaccine (serotype-4/8b/11) provides efficient protection with long duration of immunity.

Dam-Hee Park, Kyeong-Cheol Min, Na-Ri Kim, Sung-Sik Yoo, Injoong Yoon, Jongseo Mo

Abstract read
In one paragraph

Article in Journal of veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dam-Hee ParkChoong Ang Vaccine Laboratories Co., Ltd., Daejeon 34055, Korea.ORCID https://orcid.org/0009-0001-3071-6945
Kyeong-Cheol MinChoong Ang Vaccine Laboratories Co., Ltd., Daejeon 34055, Korea.ORCID https://orcid.org/0000-0002-5666-3562
Na-Ri KimChoong Ang Vaccine Laboratories Co., Ltd., Daejeon 34055, Korea.ORCID https://orcid.org/0000-0003-2183-3645
Sung-Sik YooChoong Ang Vaccine Laboratories Co., Ltd., Daejeon 34055, Korea.ORCID https://orcid.org/0009-0000-6081-5971
Injoong YoonChoong Ang Vaccine Laboratories Co., Ltd., Daejeon 34055, Korea.ORCID https://orcid.org/0000-0002-8761-4296
Jongseo MoCollege of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea. mo.js23@yu.ac.kr.ORCID https://orcid.org/0000-0003-1660-8646

Funding

Ministry of Agriculture, Food and Rural Affairs 320005-4
6 · The paper itself

Abstract

importanceFowl adenovirus (FAdV) is a significant viral pathogen with major economic impact on the global poultry industry. Recent epidemiological studies indicate that predominant strains in Asia, including Korea, are FAdV-4 (species C), 8b (species E), and 11 (species D).

objectiveThis study evaluated a novel trivalent inactivated FAdV vaccine containing antigens from FAdV-4, 8b, and 11.

methodsAn SD1356-like FAdV-8b strain, representing newly emerging variants in Asia and the Middle East, was included as an immunogen. Prior to vaccination-challenge trials, pathogenicity of FAdV-4, 8b, and 11 was assessed in chickens via oral, intramuscular, and intravenous routes. These models were used to determine the minimum protective dose. Cross-neutralization assays were performed using sera from monovalent vaccinations for each serotype. Duration of immunity was evaluated in specific pathogen-free chickens following a single vaccine dose.

resultsIntravenous challenge produced the highest mortality across all serotypes, including the relatively low-pathogenic FAdV-11. A vaccine dose of 10 CONCLUSIONS AND RELEVANCE: The trivalent vaccine provides effective protection against predominant FAdV-4, 8b, and 11 strains. These findings support the use of multivalent vaccines to achieve broad and sustained immunity against emerging FAdV infections in poultry.

Indexed as

Adenoviridae InfectionsAviadenovirusChickensPoultry DiseasesViral VaccinesAnimalsAntibodies, ViralSpecific Pathogen-Free OrganismsVaccines, InactivatedAntibodies, ViralVaccines, InactivatedViral Vaccineshydropericardium syndromeimmunityinclusion body hepatitispathogenicityVaccine

Identifiers

PMID42225601
PMCPMC13236471

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.