Evidence map›Paper›PMID 42225600›Full record

ArticleJournal of veterinary science2026

Swine TRIM25 inhibits vesicular stomatitis virus replication by activation of type I IFN signaling pathway and binding vRNA.

Ying Cao, Jinxia Zhang, Dongwan Yoo, Haowen Zhang, Dandan Jiang, Yue Hu, Xiaoyan Cong, Juntong Li, Xiangju Wu, Yijun Du and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ying CaoCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.ORCID https://orcid.org/0009-0001-4589-5616
Jinxia ZhangKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.ORCID https://orcid.org/0009-0009-6797-6554
Dongwan YooDepartment of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.ORCID https://orcid.org/0000-0002-6730-9729
Haowen ZhangCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.ORCID https://orcid.org/0009-0005-0759-8716
Dandan JiangKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.ORCID https://orcid.org/0009-0005-7421-7653
Yue HuKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.ORCID https://orcid.org/0000-0002-8290-9845
Xiaoyan CongKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.ORCID https://orcid.org/0000-0002-7567-9914
Juntong LiKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.ORCID https://orcid.org/0009-0002-5299-3908
Xiangju WuKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China. wuxiangju900426@163.com.ORCID https://orcid.org/0000-0002-2489-7743
Yijun DuCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.ORCID https://orcid.org/0000-0001-9215-4637
Jing QiCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.ORCID https://orcid.org/0000-0002-5688-5579
Juan HuangCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China. juanhuang@qau.edu.cn.ORCID https://orcid.org/0000-0002-8671-1334

Funding

China Postdoctoral Science Foundation 2024M761865Key Research and Development Program of Shandong Province 2022CXPT010National Key Research and Development Program of China 2021YFD1800300National Key Research and Development Program of China 2023YFD1800304National Natural Science Foundation of China 32373094Natural Science Foundation of Shandong Province ZR2023MC076Shandong Academy of Agricultural Sciences CXGC2025A04Shandong Academy of Agricultural Sciences CXGC2025C10Shandong Province Pig Industry Technology System SDAIT-08-07Shandong Province Science and Technology based Small and Medium sized Enterprises Innovation Capability Enhancement Project 2024TSGC0274Special Fund Project for Guiding Local Science and Technology Development by the Central Government YDZX2024019
6 · The paper itself

Abstract

importanceVesicular stomatitis virus is a zoonotic rhabdovirus that infects livestock and can cause economically important disease. Tripartite motif-containing 25 (TRIM25) is an E3 ubiquitin ligase involved in innate antiviral signaling, but its role in pigs during vesicular stomatitis virus infection is unclear.

objectiveTo define the mechanism by which swine TRIM25 restricts vesicular stomatitis virus replication.

methodsPorcine 3D4/21 cells with TRIM25 overexpression or knockdown were infected with vesicular stomatitis virus. Viral replication was quantified by immunoblotting, quantitative reverse transcription polymerase chain reaction, and 50% tissue culture infectious dose assays. Type I interferon signaling was assessed by transcript quantification, interferon-beta and interferon-stimulated response element reporter assays, and co-immunoprecipitation. Viral RNA binding was tested by RNA immunoprecipitation.

resultsTRIM25 overexpression reduced viral RNA and infectious titers, whereas TRIM25 knockdown increased replication ( CONCLUSIONS AND RELEVANCE: Porcine TRIM25 restricts vesicular stomatitis virus replication by amplifying type I interferon signaling and directly binding viral RNA.

Indexed as

Interferon Type ISignal TransductionSwine DiseasesTripartite Motif ProteinsUbiquitin-Protein LigasesVesicular StomatitisVesicular stomatitis Indiana virusVesiculovirusVirus ReplicationAnimalsCell LineRNA, ViralSwineInterferon Type IRNA, ViralTripartite Motif ProteinsUbiquitin-Protein Ligasesinnate immunityRIG-I receptorRNA binding proteinsubiquitinationVesicular stomatitis virus innate response

Identifiers

PMID42225600
PMCPMC13236469

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.