Defining cell surface and glycosylated RNAs.

Eddy Tzintzun-Tapia, Fardin Aryan, Ryan A Flynn

Abstract readReview

In one paragraph

Review in Trends in genetics : TIG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eddy Tzintzun-TapiaStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Fardin AryanStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Ryan A FlynnStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. Electronic address: ryan.flynn@childrens.harvard.edu.

Funding

Mechanisms and functions of cell surface glycoRNAsR35GM151157 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI Ryan Alexander Flynn · 2023 to 2026

$1.8M

NIGMS NIH HHS R35 GM151157

6 · The paper itself

Abstract

The cell surface is a dynamic interface for biomolecular interactions, classically considered to be governed by proteins, lipids, and glycans. Advances in chemical biology and RNA detection have revealed that RNA molecules also reside at the cell surface. We initially identified a class of these resident RNAs as small noncoding RNAs covalently modified with N-glycans, termed glycoRNAs. In this review article, we discuss the technologies that have enabled the identification of glycoRNAs and the more general concept of cell surface RNAs. We also highlight emerging evidence for the trafficking of RNA to the extracellular space and the mechanisms that anchor RNA to the surface of living cells. These observations have reshaped our understanding of RNA regulatory mechanisms and encourage further investigation into previously unrecognized functions of RNAs.

Indexed as

cell surfaceglycobiologyglycoRNAnoncoding RNAsequencing technologies

Identifiers

PMID42225521

DOI10.1016/j.tig.2026.05.002

PMCPMC13232687

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.