Evidence map›Paper›PMID 42225303›Full record

ArticleDiabetes, obesity & metabolism2026

Glycaemic Control by Sociodemographic Factors in Adults With Type 1 Diabetes in England: Trends From 2007-2008 to 2023-2024.

Muhammad Saleem Khan, Jonathan Valabhji, Naveed Sattar, Helen Murphy, Fulya Mehta, Partha Kar, Clare Hambling, Kamlesh Khunti, Garry D Tan, Naomi Holman

Abstract read
In one paragraph

Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muhammad Saleem KhanSchool of Public Health, Imperial College London, London, UK.ORCID 0000-0001-6092-2021
Jonathan ValabhjiDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Chelsea and Westminster Hospital Campus, Imperial College London, London, UK.
Naveed SattarSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID 0000-0002-1604-2593
Helen MurphyNorwich Medical School, University of East Anglia, Norwich, UK.
Fulya MehtaAlder Hey Children's NHS Foundation Trust, Liverpool, UK.
Partha KarPortsmouth Hospitals University NHS Trust, Portsmouth, UK.
Clare HamblingLitcham Health Centre, Norfolk, UK.
Kamlesh KhuntiDiabetes Research Centre, College of Life Sciences, Leicester General Hospital, University of Leicester, Leicester, UK.ORCID 0000-0003-2343-7099
Garry D TanOxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals Foundation Trust, Oxford, UK.
Naomi HolmanSchool of Public Health, Imperial College London, London, UK.ORCID 0000-0002-7432-5786

Funding

CW+NHS EnglandNorthwest London National Institute for Health and Care Research (NIHR) Applied Research Collaboration (ARC)
6 · The paper itself

Abstract

aimsThis study evaluated trends in glycaemic control in adults with Type 1 diabetes in England from 2007-2008 to 2023-2024, stratified by age, sex, ethnicity and socioeconomic deprivation. MATERIALS AND

methodsAdults aged ≥ 20 years from the National Diabetes Audit were analysed. Trends in mean HbA1c were assessed using linear mixed-effects models. Logistic regression examined associations between sociodemographic factors and having an HbA1c ≤ 58 mmol/mol (≤ 7.5%); odds ratios were converted to relative risks.

resultsIn 2007-2008, 32.6% of 133 035 adults had an HbA1c ≤ 58 mmol/mol, increasing to 39.1% of 226 005 adults in 2023-2024. Mean HbA1c declined from 68.8 (95% CI: 68.6-69.0) to 66.2 mmol/mol (95% CI: 66.1-66.3). By age, the largest improvement occurred in those aged 20-24 years, from 76.7 to 70.1 mmol/mol (p < 0.001), while adults > 64 years saw a non-significant increase from 63.7 to 63.8 mmol/mol (p = 0.203). Women consistently had higher mean HbA1c than men (2023-2024: 66.1 vs. 65.8 mmol/mol), declining from 69.4 to 66.1 mmol/mol in women and from 68.4 to 65.8 mmol/mol in men (both p < 0.001) and a lower adjusted probability of threshold attainment (38.4% [95% CI: 38.0-39.4] vs. 38.7% [95% CI: 38.2-39.3]). Marked ethnic inequalities persisted in 2023-2024: mean HbA1c was highest in Black (72.1 mmol/mol, 95% CI: 71.5-72.7) and Asian adults (69.8 mmol/mol, 95% CI: 69.4-70.2) compared with White adults (65.3 mmol/mol, 95% CI: 65.1-65.5). Socioeconomic gradients remained substantial, with threshold attainment at 46.4% (95% CI: 45.6-47.2) in the least deprived versus 32.3% (95% CI: 31.4-33.9) in the most deprived group.

conclusionsAlthough HbA1c improved overall, inequalities by age and deprivation widened, highlighting the need for equitable targeted care.

Indexed as

Diabetes Mellitus, Type 1Glycemic ControlAdultAgedBlood GlucoseEnglandFemaleGlycated HemoglobinHumansMaleMiddle AgedSociodemographic FactorsSocioeconomic Disparities in HealthSocioeconomic FactorsYoung AdultBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanglycaemic controlobservational studyreal‐world evidenceType 1 diabetes

Identifiers

PMID42225303
PMCPMC13341392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.