Evidence map›Paper›PMID 42225280›Full record

ArticleJournal of medicinal chemistry2026

C-BODIPY Dyads Based on Fused-Ring Organoboron Scaffolds for Efficient Photodynamic Therapy Targeting

Karolina A Urbanowicz, Paulina H Marek-Urban, Karolina Wrochna, Marta Rogalska, Anna Lewandowska-Andrałojć, Kamil Kotwica, Sandra Pluczyk-Małek, Agata Blacha-Grzechnik, Izabela Nasiłowska, Maciej Trzaskowski and 4 more

Abstract read
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In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Karolina A UrbanowiczFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland.
Paulina H Marek-UrbanFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland.
Karolina WrochnaFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland.
Marta RogalskaFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland.
Anna Lewandowska-AndrałojćFaculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, Poznań 61-712, Poland.
Kamil KotwicaFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland.
Sandra Pluczyk-MałekFaculty of Chemistry, Silesian University of Technology, Strzody 9, Gliwice 44-100, Poland.
Agata Blacha-GrzechnikFaculty of Chemistry, Silesian University of Technology, Strzody 9, Gliwice 44-100, Poland.
Izabela NasiłowskaFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland.
Maciej TrzaskowskiCentre for Advanced Materials and Technologies, Warsaw University of Technology, Poleczki 19, Warsaw 02-822, Poland.ORCID 0000-0001-5892-1898
Julia GdeszFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland.
Jolanta MierzejewskaFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland.ORCID 0000-0002-9298-8794
Monika StaniszewskaCentre for Advanced Materials and Technologies, Warsaw University of Technology, Poleczki 19, Warsaw 02-822, Poland.
Krzysztof DurkaFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland.ORCID 0000-0002-6113-4841

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of heavy-atom-free C-BODIPY photosensitizers based on five different types of fused-ring organoboron scaffolds was designed for the application in antifungal photodynamic therapy. The dyes were functionalized with a positively charged quaternary ammonium group or zwitterionic 3-(ethyldimethylammonio)propane-1-sulfonate unit. Spectroscopic, electrochemical, and photocatalytic studies supported by DFT calculations revealed the crucial role of the organoboron structure on triplet-state generation. Most of the BODIPY complexes display high ROS generation with a type I/type II ROS ratio depending on the electronic structure of the boracycle unit. Antifungal studies demonstrated remarkable efficacy against the opportunistic yeast

Indexed as

Antifungal AgentsBiofilmsBoron CompoundsCandida albicansPhotochemotherapyPhotosensitizing AgentsMicrobial Sensitivity TestsReactive Oxygen Species4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneAntifungal AgentsBoron CompoundsPhotosensitizing AgentsReactive Oxygen Species

Identifiers

PMID42225280
PMCPMC13308890

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.