Evidence map›Paper›PMID 42224953›Full record

ReviewTranslational oncology2026

Advances in deciphering intratumoral versus peritumoral heterogeneity of infiltrating lymphocytes in pancreatic cancer: a spatial perspective.

Ke Zhao, Qiting Yang, Yuhan Yan, Jiyun Zhu, Siming Zheng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ke ZhaoThe Second School of Clinical Medicine Faculty of Zhejiang TCM College, Hangzhou, China.
Qiting YangSchool of Medicine, Qingdao Qiushi Vocational and Technical College, Qingdao China.
Yuhan YanThe Third School of Clinical Medical Faculty of Zhejiang TCM College, Hangzhou, China.
Jiyun ZhuHepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Siming ZhengHepatopancreatobiliary Surgery Department, The First Affiliated Hospital of Ningbo University, Ningbo, China. Electronic address: zhengsiming1221@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by a profoundly immunosuppressive and spatially heterogeneous tumor microenvironment. Recent research has focused on the distinct topographic distribution of tumor-infiltrating lymphocytes (TILs) across intratumoral and peritumoral compartments. This review synthesizes the latest advances, delineating the distribution, functional states, and ontogeny of region-specific TIL subsets, and dissects how spatial heterogeneity fuels disease progression and resistance to immunotherapy. We further explore the reciprocal crosstalk between immunosuppressive stroma and lymphocyte heterogeneity, highlight prevailing technical and conceptual challenges, and outline emerging technologies poised to shape the next phase of discovery. This work provides a comprehensive roadmap to accelerate translation in PDAC immuno-oncology.

Indexed as

ImmunotherapyPancreatic cancerSpatial distributionTumor-infiltrating lymphocytesTumor microenvironment

Identifiers

PMID42224953
PMCPMC13253092

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.