Evidence map›Paper›PMID 42224858›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2026

A CYP3A7 metabolically competent human induced pluripotent stem cell-derived hepatocyte-like cell (hHLC

Emily G Gracey, Sylvie E Kandel, Jed N Lampe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Emily G GraceyDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Sylvie E KandelDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Jed N LampeDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Electronic address: jed.lampe@cuanschutz.edu.

Funding

Understanding the underlying toxicological mechanisms of drug-hormone interactions to improve the safety profile of antiviral medications in pregnant people, developing fetuses, and neonatesR01AI183687 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Jed Noah Lampe · 2024 to 2026
$1.7M
NIAID NIH HHS R01 AI183687
6 · The paper itself

Abstract

Drug safety assessment in newborns is limited by ethical constraints and the fact that no appropriate human-relevant in vitro hepatic cell model system currently exists to study and predict drug metabolism and disposition in this fragile population. Yet polypharmacy and off-label drug administration to newborns in the neonatal intensive care unit substantially increases the risk for drug adverse events in a population characterized by an immature hepatic drug metabolizing enzyme (DME) system. To address this concern, we differentiated induced pluripotent stem cells from adult donors into human hepatocyte-like cells (hHLC

Indexed as

Cytochrome P-450 CYP3AHepatocytesInduced Pluripotent Stem CellsCell DifferentiationCells, CulturedHumansInfant, NewbornCYP3A7 protein, humanCytochrome P-450 CYP3ACytochrome P450 CYP3A7Human iPSC-derived hepatocyte-like cellPostnatal drug metabolism

Identifiers

PMID42224858
PMCPMC13632510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.