ArticleClinics (Sao Paulo, Brazil)2026
Triglyceride-glucose and TyG-BMI indexes predict acute pancreatitis in adult critically ill patients admitted to intensive care.
Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe Triglyceride-Glucose Index (TyG) has emerged as a convenient surrogate marker of insulin resistance and has been linked to various metabolic disorders. However, its relationship with Acute Pancreatitis (AP) in adult critically ill patients remains unclear.
methodsThe authors analyzed 2,588 adult critically ill patients from the MIMIC database. Participants were stratified by median TyG and TyG-BMI indices. Logistic regression, restricted cubic spline, and subgroup analyses evaluated associations with AP risk. ROC curves assessed predictive performance.
resultsHigh TyG and TyG-BMI groups exhibited greater metabolic derangements, longer ICU/hospital stays, and higher comorbidity burden. AP patients (9.4%) had elevated TyG levels (9.9 vs. 8.7, p < 0.001). Both indices were independently associated with AP risk in continuous, IQR, and quartile analyses (TyG: OR per IQR = 2.08, 95% CI 1.75-2.48; TyG-BMI: OR per IQR = 1.34, 95% CI 1.12-1.58). TyG showed linear dose-response, whereas TyG-BMI exhibited nonlinear associations. Associations were consistent across subgroups. ROC analysis indicated superior predictive ability for TyG (AUC = 0.809) versus TyG-BMI (AUC = 0.787, p = 0.00227).
conclusionBoth TyG and TyG‑BMI indices are independent predictors of acute pancreatitis, with TyG demonstrating a statistically higher but modestly improved discriminative performance.
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