Evidence map›Paper›PMID 42224780›Full record

ArticleBrazilian journal of otorhinolaryngology

Effects of obstructive sleep apnea on circulating immune cells profiles: Evidence from NHANES dataset and Mendelian randomization.

Yajie Jia, Xiang Gao, Shenglong Xu, Jingli Shi, Haifeng Hou, Yanru Li, Demin Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yajie JiaCapital Medical University, Beijing Tongren Hospital, Department of Otolaryngology Head and Neck Surgery, Beijing, China; Key Laboratory of Otorhinolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, China; Capital Medical University, Obstructive Sleep Apnea-Hypopnea Syndrome Clinical Diagnosis and Therapy and Research Centre, Beijing, China.
Xiang GaoCapital Medical University, Beijing Tongren Hospital, Department of Otolaryngology Head and Neck Surgery, Beijing, China; Key Laboratory of Otorhinolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, China; Capital Medical University, Obstructive Sleep Apnea-Hypopnea Syndrome Clinical Diagnosis and Therapy and Research Centre, Beijing, China; Department of Otorhinolaryngology Head and Neck Surgery, Peking university First Hospital, Beijing, China.
Shenglong XuCapital Medical University, Beijing Tongren Hospital, Department of Otolaryngology Head and Neck Surgery, Beijing, China.
Jingli ShiCapital Medical University, Beijing Tongren Hospital, Department of Otolaryngology Head and Neck Surgery, Beijing, China.
Haifeng HouEdith Cowan University, School of Medical and Health Sciences, Centre for Precision Health, Perth, Australia; Shandong First Medical University and Shandong Academy of Medical Sciences, School of Public Health, Taian, China.
Yanru LiCapital Medical University, Beijing Tongren Hospital, Department of Otolaryngology Head and Neck Surgery, Beijing, China; Key Laboratory of Otorhinolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, China; Capital Medical University, Obstructive Sleep Apnea-Hypopnea Syndrome Clinical Diagnosis and Therapy and Research Centre, Beijing, China.
Demin HanCapital Medical University, Beijing Tongren Hospital, Department of Otolaryngology Head and Neck Surgery, Beijing, China; Key Laboratory of Otorhinolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, China; Capital Medical University, Obstructive Sleep Apnea-Hypopnea Syndrome Clinical Diagnosis and Therapy and Research Centre, Beijing, China; Xinjiang Medical University, Xinjiang Key Laboratory of Biopharmaceuticals and Medical Devices, Xinjiang, China. Electronic address: deminhan_ent@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to investigate the impact of Obstructive Sleep Apnea (OSA) on immune cell profiles by utilizing both the National Health and Nutrition Examination Survey (NHANES) dataset and a two-sample Mendelian Randomization (MR) method.

methodsWe included 20,732 participants from the NHANES to explore the relationship between symptom defined OSA and peripheral immune cells. Additionally, we conducted a two-sample MR analysis to investigate the effect of OSA on 35 summarized peripheral immune cell properties and 731 immunophenotypes. To ensure the robustness of findings in MR analysis, we conducted a sensitivity analysis.

resultsThe NHANES dataset and MR analysis indicated that OSA patients exhibit significantly elevated levels of white blood cells, neutrophils, and granulocytes, along with lower levels of lymphocytes. Furthermore, the MR analysis demonstrated a causal link between genetic predisposition to OSA and ten lymphocyte subtypes. Notably, there is a decrease in CD3 expression on Natural Killer-T (NKT) cells (β

conclusionOSA is associated with elevated neutrophils, granulocytes, and systemic immune-inflammation index. Causally, OSA reduces NKT cells and disrupts lymphocyte homeostasis, impairing B-cell maturation/activation. These immune signatures may serve as clinical biomarkers for guide risk stratification and guide personalized therapies, including targeted immunomodulation. LEVEL OF EVIDENCE: This study combined a cross-sectional analysis of NHANES datasets with a Mendelian Randomization (MR) approach utilizing GWAS datasets. The MR analysis provides a level of evidence second only to randomized controlled trials, surpassing that of cohort and case-control studies.

Indexed as

Sleep Apnea, ObstructiveAdultFemaleGenetic Predisposition to DiseaseHumansImmunophenotypingMaleMendelian Randomization AnalysisMiddle AgedNutrition SurveysCirculating immune cellsMendelian randomizationNational Health and Nutrition Examination Survey (NHANES)Obstructive sleep apnea

Identifiers

PMID42224780
PMCPMC13241890

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.