Evidence map›Paper›PMID 42224599›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

From bedside to bench: A multimodal approach uncovering the molecular basis of the

Aishwarya S Iyer, Nathan T Wright, Mary E Cook, Yasuharu Takagi, Bruce A Johnson, Valérie Biancalana, Marie Massier, Marta Spodenkiewicz, Céline Poirsier, Brice Vallecillo and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. From bedside to bench: A multimodal approach uncovering the molecular basis of theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aishwarya S IyerDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201.
Nathan T WrightDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807.ORCID 0000-0003-0177-6129
Mary E CookThe Center for Biomolecular Therapeutics, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201.
Yasuharu TakagiLaboratory of Molecular Physiology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Bruce A JohnsonStructural Biology Initiative, The City University of New York Advanced Science Research Center, New York, NY 10031.ORCID 0000-0001-8445-5368
Valérie BiancalanaLaboratory of Genetic Diagnosis, Faculty of Medicine, Centre Hospitalier Régional Universitaire, Strasbourg 67091, France.
Marie MassierDepartment of Genetics, Reims University Hospital, Reims 51092, France.ORCID 0009-0002-3535-0847
Marta SpodenkiewiczDepartment of Genetics, Reims University Hospital, Reims 51092, France.
Céline PoirsierDepartment of Genetics, Reims University Hospital, Reims 51092, France.
Brice VallecilloNeuromuscular diseases Reference Center, Department of Physical and Rehabilitation Medicine, Reims University Hospital, Sebastopol Hospital, Centre Hospitalier Universitaire de Reims, UR3797, VieFra, Reims Champagne-Ardenne University, Reims 51092, France.
François Constant BoyerNeuromuscular diseases Reference Center, Department of Physical and Rehabilitation Medicine, Reims University Hospital, Sebastopol Hospital, Centre Hospitalier Universitaire de Reims, UR3797, VieFra, Reims Champagne-Ardenne University, Reims 51092, France.
Charlotte PineauPediatric Electrophysiology Department, Reims University Hospital, Reims 51092, France.
Lindsey HensleyDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807.
James R SellersLaboratory of Molecular Physiology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-6296-564X
Kristen M VarneyDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201.
David J WeberDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0002-8824-1110
Aikaterini Kontrogianni-KonstantopoulosDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0003-3948-1959

Funding

Research Training in Gastroenterology and HepatologyT32DK067872 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI RAUFMAN, JEAN-PIERRE · 2005 to 2024
$7.2M
HHS | NIH (NIH) AR076373HHS | NIH (NIH) GM145397HHS | NIH (NIH) HL00429NIDDK NIH HHS T32 DK067872NSF (NSF) 2024182
6 · The paper itself

Abstract

Myotrem is an untreatable, early-onset, congenital myopathy characterized by hypotonia, muscle weakness, skeletal deformities, dysmorphia, respiratory insufficiency, and myogenic tremor (V. Shashi

Indexed as

Carrier ProteinsMuscular DiseasesHumansMaleMuscle, SkeletalMutationMyosin Binding Protein CMyosinsProtein BindingProtein DomainsCarrier ProteinsMyosin Binding Protein CMyosinsM-domainMyotrem myopathyslow Myosin Binding Protein-Cstructure and protein dynamics

Identifiers

PMID42224599
PMCPMC13250559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.