Evidence map›Paper›PMID 42224591›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain.

Minjun Liu, Madison Hung, Ellen Kozlov, Megan Hung, Mariana Colaço-Gaspar, Shristi Roy, Yiping Tu, Shino D Magaki, Christopher K Williams, Maarja Andaloussi Mäe and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Minjun Liu *Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.
Madison Hung *Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.
Ellen Kozlov *Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.
Megan HungDepartment of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.
Mariana Colaço-GasparDepartment of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.
Shristi RoyDepartment of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.
Yiping TuDepartment of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.ORCID 0000-0002-4630-9113
Shino D MagakiDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.ORCID 0000-0003-0433-5759
Christopher K WilliamsDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.
Maarja Andaloussi MäeDepartment of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala 75185, Sweden.ORCID 0000-0001-6985-4379
Erik C B JohnsonDepartment of Neurology, Emory University, Atlanta, GE 30329.
Robert W SiegelLaboratory for Experimental Medicine, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46225.ORCID 0000-0002-0833-5580
Robert J KonradLaboratory for Experimental Medicine, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46225.ORCID 0000-0003-0923-0542
Michael PlougFinsen Laboratory Copenhagen University Hospital-Rigshospitalet, Copenhagen N DK-2200, Denmark.ORCID 0000-0003-2215-4265
Christer BetsholtzDepartment of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala 75185, Sweden.
Anne P BeigneuxDepartment of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.ORCID 0000-0002-7892-150X
Liqun HeDepartment of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala 75185, Sweden.ORCID 0000-0003-2127-7597
Loren G FongDepartment of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.ORCID 0000-0002-4465-5290
Stephen G YoungDepartment of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095.ORCID 0000-0001-7270-3176

Funding

Refining Physiologic Mechanisms for Intravascular Triglyceride MetabolismR01HL087228 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEIGNEUX, ANNE, FONG, LOREN GI · 2007 to 2024
$7.8M
Solving longstanding mysteries in plasma triglyceride metabolismR01HL171737 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNE BEIGNEUX, Loren Gi Fong · 2024 to 2026
$1.9M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL171737 HL087228 HL176438 HL139725Leducq Foundation 23CVD02NHLBI NIH HHS R01 HL087228NHLBI NIH HHS R01 HL171737Swedish Research Council 2023-02655; 2015-00550The John and Birthe Meyer Foundation 000
6 · The paper itself

Abstract

In peripheral tissues, lipoprotein lipase (LPL) is secreted by parenchymal cells (adipocytes, myocytes) into the interstitial spaces, where it is captured by GPIHBP1 (a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells) and escorted to the luminal surface of capillaries. The LPL inside capillaries hydrolyzes glycerolipids in the plasma lipoproteins, releasing fatty acids for parenchymal cells. In the central nervous system, LPL is synthesized by multiple cell types [e.g., microglia, oligodendrocyte precursor cells (OPCs)] and secreted into the interstitium, but a binding site for the LPL has never been identified. By examining single nuclei RNA-seq databases of the human brain, we found that

Indexed as

BrainLipoprotein LipaseOligodendrogliaReceptors, LipoproteinAnimalsHumansProtein BindingGPIHBP1 protein, humanLipoprotein LipaseLPL protein, humanReceptors, LipoproteinGPIHBP1lipoprotein lipasemyelinoligodendrocyte

Identifiers

PMID42224591
PMCPMC13250511

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.