ArticleJournal of veterinary internal medicine2026
Serial evaluation of clinical, functional, and structural pulmonary changes in 10 dogs with leptospirosis.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLeptospirosis is a worldwide zoonosis with multisystemic consequences, including the pulmonary hemorrhage syndrome associated with a high mortality rate in dogs. HYPOTHESIS/
objectivesSerial assessment of clinical, functional, and structural pulmonary changes in dogs with acute leptospirosis during the first 8 days of hospitalization. ANIMALS: Ten client-owned dogs diagnosed with leptospirosis.
methodsProspective, descriptive case series with daily clinical examination, arterial blood gas analyses on d1-4, d6, and d8 and thoracic computed tomography (CT) with pulmonary segmentation and lung densitometry analysis on d1, d4, and d8.
resultsClinical respiratory impairment was observed in most dogs during the measurement period, including 1 dog with fatal pulmonary hemorrhage. Half of the dogs showed hypoxemia (arterial partial pressure of oxygen: median, 56.6 mmHg; range, 49.6-67.8 mmHg) with increased alveolar-arterial PO2 gradient (A-a gradient) (37.9 mmHg [21.9-405.4 mmHg]) over the study period. Alveolar ventilation was only minimally affected (arterial partial pressure of carbon dioxide 35.2 mmHg [25.9-42.1 mmHg]). Quantitative CT analyses identified increased mean lung attenuation (MLA) in all dogs initially (-612 HU [-475 to -681 HU]) with progressive improvement in most dogs (d4: -646 HU [-583 to -746 HU]; d8: -709 HU [-624 to -811 HU]). Whereas clinical score and CT changes improved progressively in most dogs, the blood gas results showed a fluctuating pattern. CONCLUSIONS AND CLINICAL IMPORTANCE: The clinical pulmonary manifestations of these dogs with leptospirosis were characterized by hypoxemia, increased A-a gradient, and increased lung density. The clinical course seemed to more closely parallel the structural changes observed on CT rather than the functional alterations assessed with arterial blood gas analyses.
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