ArticleThe Journal of organic chemistry2026
Investigating the P450-Mediated Cross-Linking of the Atypical GPA Complestatin Using Alternate Peptide Probes.
Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Synthesis of Glycopeptide Antibiotic Peptide Substrates Using Knorr-Pyrazole Chemistry.ChemMedChem · 2026Article
- A Machine Learning-Based Genome Mining Approach Reveals Unprecedented Biarylitide Diversity.JACS Au · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glycopeptide antibiotics (GPAs) are clinically relevant antibiotics defined by their highly cross-linked structure, which is required for their antimicrobial activity. While GPAs are typically characterized as type I-IV GPAs - heptapeptides that bind to the d-Ala-d-Ala terminus of Lipid II - an expansion of these subtypes has recently been seen for type V GPAs that possess altered structural characteristics and mechanisms of action. The major structural changes seen with this class are due to varied cross-linking occurring between the aromatic side chain residues, with these cross-links installed by cytochrome P450 (Oxy) enzymes that are recruited to the peptide substrate during nonribosomal peptide synthesis by a specialized recruitment domain, known as the X-domain. Given the importance of these cross-links for the structural rigidity and activity of GPAs,
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Registered trials
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