Evidence map›Paper›PMID 42224098›Full record

ArticleBJS open2026

Comparative long-term risks of chronic kidney disease and dialysis following conservative treatment, renal artery embolization, or nephrectomy in patients with blunt kidney injuries: retrospective cohort study.

Jhih-Ming Tang, Ling-Wei Kuo, Jen-Fu Huang, Chih-Po Hsu, Chi-Tung Cheng, Huan-Wu Chen, Cheng-Hsien Wu, Yon-Cheong Wong, Szu-An Chen, Chia-Cheng Wang and 4 more

Abstract readComparative Study
In one paragraph

Article in BJS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

14 authors.

Jhih-Ming TangDivision of Trauma and Emergency Surgery, Jen-Ai Hospital, Dali Branch, Taichung, Taiwan.
Ling-Wei KuoDivision of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.ORCID 0000-0001-6489-3723
Jen-Fu HuangDivision of Trauma and Emergency Surgery, Jen-Ai Hospital, Dali Branch, Taichung, Taiwan.ORCID 0000-0001-8185-8372
Chih-Po HsuDivision of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Chi-Tung ChengDivision of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Huan-Wu ChenSchool of Medicine, Chang Gung University, Taoyuan, Taiwan.
Cheng-Hsien WuSchool of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yon-Cheong WongSchool of Medicine, Chang Gung University, Taoyuan, Taiwan.
Szu-An ChenDivision of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Chia-Cheng WangDivision of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Yu-San TeeDivision of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Chun-Hsiang Ou YangDivision of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Chih-Yuan FuDivision of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.ORCID 0000-0003-1536-1549
Chien-Hung LiaoDivision of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.

Funding

Jen-Ai Medical Foundation, Taichung, Taiwan JMRPGJQ0141
6 · The paper itself

Abstract

backgroundLong-term changes in renal function following blunt kidney injury (BKI) remain insufficiently studied, particularly in patients who undergo renal artery embolization (RAE). The aim of this study was to clarify the long-term risks of chronic kidney disease (CKD) and dialysis in patients with BKI after unilateral nephrectomy, RAE, or conservative treatment. The hypothesis was that both unilateral nephrectomy and RAE would increase these risks compared with conservative treatment, with RAE posing a lower risk.

methodsThis retrospective cohort study used data from Taiwan's National Health Insurance Research Database from 2001 to 2019, focusing on patients with BKIs. Outcomes included long-term CKD risks, lifelong dialysis, and all-cause mortality. Inverse probability of treatment weighting was used to minimize confounding.

resultsDuring the study, 19 013 patients were diagnosed with BKIs; of these, 12 709 were analysed (unilateral nephrectomy, 274 (2.1%); RAE, 510 (4.0%); conservative treatment, 11 925 (93.8%)). The mean(standard deviation) age was 39.7(17.1) years, 69.4% were male, and the mean follow-up duration was 10.7(5.2) years. Compared with conservative treatment, patients undergoing unilateral nephrectomy (subdistribution hazard ratio (SHR) 1.97; 95% confidence interval (c.i.) 1.86 to 2.10) or RAE (SHR 1.17, 95% c.i. 1.09 to 1.26) had a higher risk of CKD. In addition, patients in the nephrectomy and RAE groups had an increased risk of lifelong dialysis, with an SHR of 3.97 (95% c.i. 3.09 to 5.10) and 1.46 (95% c.i. 1.07 to 1.99), respectively. Unilateral nephrectomy was associated with a higher risk of all-cause mortality than RAE and conservative treatment, with hazard ratios of 1.14 (95% c.i. 1.06 to 1.23) and 1.63 (95% c.i. 1.52 to 1.75), respectively.

conclusionsPatients with BKIs are at higher risk of long-term CKD and potential lifelong dialysis after both unilateral nephrectomy and RAE, with RAE presenting a lower risk than nephrectomy. Patients with BKIs who undergo unilateral nephrectomy or RAE require follow-up to monitor renal function and receive health education on kidney protection.

Indexed as

Conservative TreatmentEmbolization, TherapeuticKidneyNephrectomyRenal ArteryRenal DialysisRenal Insufficiency, ChronicWounds, NonpenetratingAdultFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsTaiwanabdominal injuriescompeting risk analysisend-stage kidney diseaseinverse probability of treatment weightingrenal preservationtrauma surgery

Identifiers

PMID42224098
PMCPMC13224839

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.