Evidence map›Paper›PMID 42223900›Full record

ArticleEJNMMI radiopharmacy and chemistry2026

Scaling the production of bromine-76 and bromine-77 labeled poly-ADP-ribose-polymerase-targeted theranostics for preclinical use.

Taylor R Johnson, Hong Beom Lee, Yngve Guttormsen, Jason C Mixdorf, Todd E Barnhart, Jonathan W Engle, Paul A Ellison

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Taylor R JohnsonDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Hong Beom LeeDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Yngve GuttormsenDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Jason C MixdorfDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Todd E BarnhartDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Jonathan W EngleDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Paul A EllisonDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. paellison@wisc.edu.ORCID http://orcid.org/0000-0002-8379-7419

Funding

U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
NCI NIH HHS T32 CA009206NINR NIH HHS T32CA009206Office of Science DE-SC0020960Society of Nuclear Medicine and Molecular Imaging Mars Shot AwardU.S. Department of Defense W81XWH211035
6 · The paper itself

Abstract

backgroundBromine-76, a positron emitting radionuclide for positron emission tomography (PET) imaging, and bromine-77, an Auger electron (Ae) emitting radionuclide, make a unique halogen theranostic pair. These isotopes have previously been used to synthesize a rucaparib-derived, poly-ADP-ribose polymerase inhibitor ([

resultsIsotopically enriched cobalt selenide targets had production yields of 50.7 ± 8.7 MBq/µAh for bromine-76 and 14.5 ± 3.3 MBq/µAh for bromine-77, consistent with previous reports. Adoption of the GE PETtrace Solid Target Platform (STP) increased target backing diameter to 22 mm. Increasing dry distillation duration from 5 to 6 min to 8-9 min and furnace temperature from 1050 to 1055 °C released 94 ± 5% (n = 17) of activity, in agreement with previous smaller targets (92 ± 13%, n = 35). Rinsing glassware and loading the quaternary methyl ammonium (QMA) anion exchange cartridge in 1 mM sodium bicarbonate reduced [

conclusionThe new target production technique made targets suitable for long-term use with the GE PETtrace STP. Following modifications to the distillation process, [

Indexed as

Bromine-76Bromine-77Dry distillationPARP inhibitorRadiobromineRadionuclide production

Identifiers

PMID42223900
PMCPMC13437825

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.