ArticleIrish journal of medical science2026
Association between the albumin-to-globulin ratio and deep vein thrombosis in older adults receiving home healthcare: a prospective cohort study.
Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDeep vein thrombosis (DVT) is a leading cause of morbidity and mortality in frail older adults, particularly those receiving home healthcare. Conventional diagnostic tools such as D-dimer often lack specificity in this population, creating a clinical need for accessible, reliable biomarkers.
aimThis study aimed to evaluate the predictive value of routinely available inflammatory and nutritional indices for DVT in frail elderly individuals.
methodsIn this prospective cohort study (December 2023-May 2025), frail adults aged ≥65 years receiving home healthcare were systematically evaluated for suspected DVT using Doppler ultrasonography. Demographic, clinical, and laboratory variables-including serum albumin, C-reactive protein (CRP), CRP-to-albumin ratio (CAR), albumin-to-globulin ratio (AGR), and systemic immune-inflammation index (SII)-were assessed. Logistic regression analyses identified independent predictors, while receiver operating characteristic (ROC) curves quantified diagnostic performance.
resultsAmong 161 participants, 48 were diagnosed with DVT and 113 served as controls. AGR emerged as the most robust independent predictor (OR = 0.022, 95% CI: 0.004-0.140, p < 0.001). An AGR cut-off of 1.125 yielded 75.0% sensitivity, 73.5% specificity, and an AUC of 0.742. CRP (AUC=0.651) and CAR (AUC=0.654) demonstrated moderate diagnostic accuracy, whereas albumin alone was borderline significant. DVT patients more often had Parkinson's disease, while anticoagulant use was higher among controls.
conclusionIn frail older adults, AGR emerged as the most robust biomarker for predicting DVT. Easily derived from routine laboratory tests, AGR may complement clinical evaluation and support early recognition in this vulnerable population. Larger multicenter studies are warranted to confirm these findings.
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