Evidence map›Paper›PMID 42223705›Full record

ArticleClinical and experimental medicine2026

Exosomal integrin αvβ3 derived from colorectal cancer promotes the liver pre-metastatic niche formation by inducing cancer-associated fibroblasts activation.

Jing Yu, Jiangning Xiang, Lin Yao, Shan Wang, Yifan Liu, Enli Chen, Xiaolin Liu, JinXiang Wu, Yuhao Wang, Lei Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing YuCancer Center, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong an Road, Beijing, Xi Cheng District, 100053, China.
Jiangning XiangCancer Center, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong an Road, Beijing, Xi Cheng District, 100053, China.
Lin YaoCancer Center, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong an Road, Beijing, Xi Cheng District, 100053, China.
Shan WangCancer Center, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong an Road, Beijing, Xi Cheng District, 100053, China.
Yifan LiuCancer Center, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong an Road, Beijing, Xi Cheng District, 100053, China.
Enli ChenCancer Center, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong an Road, Beijing, Xi Cheng District, 100053, China.
Xiaolin LiuCancer Center, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong an Road, Beijing, Xi Cheng District, 100053, China.
JinXiang WuCancer Center, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong an Road, Beijing, Xi Cheng District, 100053, China.
Yuhao WangCancer Center, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong an Road, Beijing, Xi Cheng District, 100053, China.
Lei ZhaoCancer Center, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong an Road, Beijing, Xi Cheng District, 100053, China. zhaoleilei0507@126.com.

Funding

National Science Foundation of China No.82203726
6 · The paper itself

Abstract

The formation of the liver pre-metastatic niche (PMN) is a critical factor in the development of colorectal cancer liver metastasis (CRLM), so understanding the mechanism of the liver PMN is crucial for the prevention and treatment of CRLM. Hepatic stellate cells (HSCs) can promote CRLM by forming cancer-associated fibroblasts (CAFs), but the mechanism remains unclear. In this study, we found that integrin αvβ3 is associated with CRLM and the poor clinical prognosis. Exosomal integrin αvβ3 derived from CRC can target HSCs via fibronectin to mediate their activation. We further explored the mechanism and found that exosomal integrin αvβ3 activates the MEK-ERK signaling pathway through the vitronectin-Integrin αvβ3-FAK axis, thereby promoting HSCs activation. After HSCs become CAFs, they promote the formation of the PMN through EMT, angiogenesis, and inflammatory factors, thereby promoting CRLM. In summary, this study clarifies that exosomal integrin αvβ3 derived from CRC can promote the formation of liver PMN by mediating HSC activation into CAFs, providing a novel therapeutic strategy for the prevention and treatment of CRLM.

Indexed as

Cancer-Associated FibroblastsColorectal NeoplasmsExosomesIntegrin alphaVbeta3Liver NeoplasmsAnimalsCell Line, TumorHepatic Stellate CellsHumansVitronectinIntegrin alphaVbeta3VitronectinCancer-associated fibroblastsColorectal cancerExosomesHepatic stellate cellIntegrin αvβ3Liver metastasis

Identifiers

PMID42223705
PMCPMC13433584

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.