Echinococcus granulosus sensu stricto hydatid cysts in human and livestock from northeastern Algeria: Molecular characterization based on nad5 and cox1 and fertility assessment.

Amina Kheninef, Ilaria Bellini, Silvia Rondòn, Claudia Chiovoloni, Lynda Aissaoui, Serena Cavallero, Stefano D'Amelio

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Article in Parasitology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Disseminated Pulmonary and Hepatic Cystic Echinococcosis Presenting as Suspected Pulmonary Embolism and Mimicking Metastatic Malignancy.Cureus · 2026
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5 · Who and what money

Authors and funding

7 authors.

Amina KheninefResearch Laboratory of Improvement and Development of Animal and Plant Production, Department of Biology and Animal Physiology, University Ferhat Abbas of Setif, Setif, Algeria.

Ilaria BelliniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy. ilaria.bellini@uniroma1.it.ORCID http://orcid.org/0009-0002-2218-7550

Silvia RondònDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

Claudia ChiovoloniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

Lynda AissaouiResearch Laboratory of Improvement and Development of Animal and Plant Production, Department of Biology and Animal Physiology, University Ferhat Abbas of Setif, Setif, Algeria.

Serena CavalleroDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

Stefano D'AmelioDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystic Echinococcosis (CE) is a major helminthic zoonosis caused by the larval stage of Echinococcus granulosus, particularly highly endemic in several Mediterranean regions, including Algeria. Humans are accidental hosts, while animals such as livestock act as intermediate hosts. This study aimed to update the fragmented epidemiological picture of CE in Algeria, by combining the knowledge on cysts fertility, and protoscolex viability with molecular strains assignment. In particular, the genetic typing of Echinococcus granulosus from humans (n = 16), cattle (n = 15), sheep (n = 15), and goat (n = 1) collected in the northeastern Setif region, were performed using two partial mitochondrial markers used for a precise strains and variant call, the classic partial cox1 and the recently developed nad5, used in this area for the first time. Results revealed a predominance of E. granulosus sensu stricto strain G1, with haplotype variants circulating in both humans and animals. Interestingly, G3 strain was reported only in a human patient, while G3 haplotype variants in both humans and animals. Fertility rate was lower but not negligible in cattle (18.2%), and high in sheep and humans (80.9% and 95.6%, respectively), and the viable cysts showed different anatomical distributions across species: in cattle, 43% were pulmonary and 57% hepatic; in sheep, 74.5% were located in the lungs and 25.5% in the liver. Such data highlights the crucial role of livestock in maintaining E. granulosus transmission in the area.

Indexed as

EchinococcosisEchinococcus granulosusAlgeriaAnimalsCattleCattle DiseasesElectron Transport Complex IVFertilityGoat DiseasesGoatsHumansLivestockSheepSheep DiseasesElectron Transport Complex IVAlgeriaCyst fertilityEchinococcus granulosus sensu strictoMt-cox1Mt-nad5

Identifiers

PMID42223666

DOI10.1007/s00436-026-08703-4

PMCPMC13447339

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