Evidence map›Paper›PMID 42223661›Full record

ArticleWorld journal of urology2026

Sport, genetic susceptibility, and the risk of benign prostatic hyperplasia: a large prospective cohort study.

Zihao Zhao, Changjing Wu, Shiliang Fu, Chao Cheng, Yang Xiong, Jiuhong Yuan, Xianding Wang, Feng Qin

Abstract read
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In one paragraph

Article in World journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Zihao ZhaoDepartment of Urology and Andrology Lab, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Changjing WuDepartment of Urology and Andrology Lab, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Shiliang FuDepartment of Urology, Jianyang People's Hospital, 180 Yiyuan Road, Sichuan Province, 641400, Jianyang, China.
Chao ChengDepartment of Urology and Andrology Lab, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Yang XiongDepartment of Urology and Andrology Lab, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Jiuhong YuanDepartment of Urology and Andrology Lab, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
Xianding WangDepartment of Urology and Andrology Lab, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, Sichuan Province, China. xiandingwang@scu.edu.cn.
Feng QinDepartment of Urology and Andrology Lab, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, Sichuan Province, China. qinfeng@scu.edu.cn.

Funding

Sichuan Provincial Science and Technology Support Program 2025YFHZ0212
6 · The paper itself

Abstract

purposeBenign prostatic hyperplasia (BPH) is a common age-related urological condition influenced by both modifiable lifestyle factors and genetic susceptibility. This large cohort study was performed to examine the association between physical activities and incident BPH, and assess modification by genetic susceptibility using a polygenic risk score (PRS).

methodsWe conducted a prospective cohort study of 80,253 men from the UK Biobank who were free of BPH and prostate cancer at baseline. Physical activity was assessed using self-reported total weekly activity time, including walking, moderate, and vigorous activities. Genetic susceptibility was quantified using a BPH-specific PRS. Cox proportional hazards models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident BPH. Multiplicative interaction between walking and genetic susceptibility was evaluated by including product terms between walking quartiles and PRS tertiles in Cox proportional hazards models.

resultsOver a median follow-up of 15.01 years, 11,926 incident BPH cases were identified. Higher total weekly physical activity was significantly associated with a lower risk of BPH, with walking showing the strongest protective association. Higher PRS was strongly and independently associated with increased BPH risk. Stratified analyses suggested a modest inverse association between walking and BPH among men with high genetic susceptibility, but the formal multiplicative interaction between walking and PRS did not reach statistical significance.

conclusionsPhysical activity and genetic susceptibility were independently associated with incident BPH. Stratified analyses suggested possible differences across genetic risk groups, but formal interaction testing did not provide robust evidence of effect modification. These observational findings are exploratory and require validation in independent cohorts.

Indexed as

ExerciseGenetic Predisposition to DiseaseProstatic HyperplasiaSportsAgedCohort StudiesGenetic Risk ScoreHumansIncidenceMaleMiddle AgedProspective StudiesRisk FactorsUK BiobankUnited KingdomBenign prostatic hyperplasiaGenetic susceptibilityPhysical activityPolygenic risk scoreProspective cohort studyUK Biobank

Identifiers

PMID42223661

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.