ReviewGenes & genomics2026
Molecular and neural mechanisms of sodium sensation.
Review in Genes & genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSodium (NaCl) is essential for neuronal excitability, muscle contraction, and osmotic balance, yet excessive intake causes cellular stress and dehydration, requiring tight homeostatic control. Drosophila melanogaster provides a genetically tractable system to dissect salt sensing and regulation.
objectiveTo summarize current understanding of concentration-dependent salt taste coding and systemic sodium homeostasis in flies.
methodsThis review integrates genetic, behavioral, electrophysiological, and physiological studies describing (1) peripheral taste receptor neurons mediating differential responses to low- versus high-salt, (2) neural circuits for appetitive versus aversive behaviors, (3) state-dependent plasticity of salt preference, and (4) post-prandial ion balancing in the gut and malpighian tubules.
resultsFlies exhibit a biphasic behavioral response to salt: low concentrations promote feeding, whereas high concentrations induce aversion. Distinct classes of gustatory receptor neurons encode these opposing valences. Salt preference is further modulated by internal physiological state, integrating sensory detection with systemic ion balance.
conclusionCoordinated sensory, neural, and excretory mechanisms govern ionic homeostasis in Drosophila melanogaster, thereby providing an evolutionarily conserved framework for investigating sodium balance across species.
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