Evidence map›Paper›PMID 42223483›Full record

Observational studyJournal of cancer research and clinical oncology2026

Predictive value of Slug-positive circulating tumor cells for neoadjuvant chemotherapy response in mesenchymal malignancies.

Niezhenghao He, Shilei Liu, Haowen Cui, Junwei Feng, Weimin Liang, Bao Yao, Fusha Amu, Baoxiu Xu, Qingxin Fan, Peng Hao

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cancer research and clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Niezhenghao He *School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Shilei Liu *School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Haowen CuiDepartment of Orthopedics, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Junwei FengDepartment of Orthopedics, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Weimin LiangDepartment of Orthopedics, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Bao YaoDepartment of Orthopedics, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Fusha AmuDepartment of Orthopedics, Liangshan Prefecture Integrated Traditional Chinese and Western Medicine Hospital, Xichang, 615000, China.
Baoxiu XuDepartment of Orthopedics, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Qingxin FanDepartment of Orthopedics, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. fqx12299@126.com.ORCID http://orcid.org/0000-0003-4694-0092
Peng HaoDepartment of Orthopedics, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. hhpeng2025@126.com.ORCID http://orcid.org/0009-0002-0663-8788

Funding

National Natural Science Foundation of China 82302754Sichuan Provincial Department of Science and Technology Project 2024NSFSC1807
6 · The paper itself

Abstract

purposeTo evaluate the predictive value of Slug-positive circulating tumor cells (CTCs) for responses to neoadjuvant chemotherapy in mesenchymal malignancies.

methodsProspective observational analysis of 59 patients receiving neoadjuvant chemotherapy. Peripheral blood was collected pre-treatment for CTC classification. Chemotherapy response was defined as complete response or partial response. Logistic regression identified factors associated with poor response. A combined model integrating Slug

resultsResponders had lower Slug

conclusionsPhenotypic heterogeneity influences neoadjuvant chemotherapy response. High Slug

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorNeoplastic Cells, CirculatingSnail Family Transcription FactorsAdultAgedFemaleHumansMaleMiddle AgedNeoadjuvant TherapyPredictive Value of TestsPrognosisProspective StudiesBiomarkers, TumorSNAI1 protein, humanSnail Family Transcription FactorsNeoadjuvant chemotherapy responsePhenotypic heterogeneityPredictive modelSlug-positive circulating tumor cells

Identifiers

PMID42223483
PMCPMC13437853

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.