Evidence map›Paper›PMID 42223470›Full record

ArticleeLife2026

Mural cells protect the adult brain from hemorrhage but do not control the blood-brain barrier in developing zebrafish.

Oguzhan F Baltaci, Andrea Usseglio Gaudi, Stefanie Dudczig, Weili Wang, Scott Paterson, Maria Cristina Rondon-Galeano, Ye-Wheen Lim, James Rae, Anne Lagendijk, Robert G Parton and 2 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Oguzhan F BaltaciOrganogenesis and Cancer Program, Peter MacCallum Cancer Centre, Melbourne, Australia.ORCID https://orcid.org/0009-0001-5651-1331
Andrea Usseglio GaudiOrganogenesis and Cancer Program, Peter MacCallum Cancer Centre, Melbourne, Australia.
Stefanie DudczigOrganogenesis and Cancer Program, Peter MacCallum Cancer Centre, Melbourne, Australia.
Weili WangInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.
Scott PatersonOrganogenesis and Cancer Program, Peter MacCallum Cancer Centre, Melbourne, Australia.
Maria Cristina Rondon-GaleanoOrganogenesis and Cancer Program, Peter MacCallum Cancer Centre, Melbourne, Australia.
Ye-Wheen LimInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.
James RaeInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.
Anne LagendijkInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.
Robert G PartonInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.ORCID https://orcid.org/0000-0002-7494-5248
Alison FarleyOrganogenesis and Cancer Program, Peter MacCallum Cancer Centre, Melbourne, Australia.
Benjamin M HoganOrganogenesis and Cancer Program, Peter MacCallum Cancer Centre, Melbourne, Australia.ORCID https://orcid.org/0000-0002-0651-7065

Funding

Australian Research Council DP210102712Australian Research Council FL210100107BrightFocus Foundation A2018807SNational Health and Medical Research Council 1155221National Health and Medical Research Council 2033008
6 · The paper itself

Abstract

The blood-brain barrier (BBB) protects the brain from circulating metabolites and plays central roles in neurological diseases. Endothelial cells (ECs) of the BBB are enwrapped by mural cells including pericytes and vascular smooth muscle cells (vSMCs) that regulate angiogenesis, vessel stability and barrier function. To explore mural cell control of the BBB, we investigated neurovascular phenotypes in zebrafish

Indexed as

Blood-Brain BarrierBrainEndothelial CellsMuscle, Smooth, VascularMyocytes, Smooth MusclePericytesZebrafishAnimalsReceptor, Platelet-Derived Growth Factor betaReceptor, Platelet-Derived Growth Factor betablood–brain barrierdevelopmental biologypericytesvascular smooth muscle cellszebrafish

Identifiers

PMID42223470
PMCPMC13225842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.