ArticleJournal of intensive care medicine2026
Early Corticosteroid use and Clinical Outcomes in Patients with Mixed and Cardiogenic Shock.
Article in Journal of intensive care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
BackgroundThe pathophysiology of CS is complex and is associated with increased inflammation and impaired vascular tone. Corticosteroids are recommended in septic shock and have been proposed as a potential treatment for other types of shock.ObjectivesWe sought to evaluate the clinical outcomes associated with early corticosteroid use in patients with cardiogenic shock (CS).MethodsUsing a nationally representative database including over 1000 hospitals, we identified adults ≥18 years of age admitted from 2015-2023 with a diagnosis of CS. Patients with adrenal insufficiency, chronic rheumatologic conditions, COVID-19 infection and acute COPD exacerbation were excluded. Using inverse probability treatment weighting (IPTW), we assessed for the association of receiving early corticosteroids (within the first 2 days of admission) versus no early corticosteroids and in-hospital mortality.ResultsOf the 167,721 identified patients with CS, the mean (SD) age was 65.5 (±15.2) years and 35.0% were women. A total of 13.2% received any corticosteroid within the first 2 days of admission. The most common corticosteroid was hydrocortisone (73.9%). Mortality for those receiving and not receiving early corticosteroids was 48.8% and 29.6% (
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