ArticleAnalytical chemistry2026
High-Throughput Reactive Desorption Electrospray Ionization Mass Spectrometry for Targeted Derivatization and Analysis of Poorly Ionized Small Molecules.
Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mass spectrometry (MS) analysis of some biologically relevant compounds is limited because of their inherently poor ionization efficiency. This challenge can often be overcome by incorporating easily ionized moieties via functional-group-targeted chemical derivatization. However, the wide variety of derivatization agents and conditions can make method development cumbersome. In this study, we employ an automated high-throughput (HT) platform based on desorption electrospray ionization (DESI) MS to rapidly screen (1 sample per second) and select appropriate derivatization strategies for poorly ionized analytes leveraging accelerated on-the-fly microdroplet reactions. This approach allowed the rapid identification of efficient derivatization strategies that were then readily applied to the qualitative and quantitative analyses of molecules of biological importance. Specifically, hydroxysteroids (e.g., cholesterol, testosterone, and cholecalciferol) were imaged in tissue sections using 4-formyl-1-methylpyridinium benzenesulfonate without the loss of the intrinsic spatial resolution of DESI, while 4-borono-
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