ArticleInvestigative ophthalmology & visual science2026
Visually Guided Saccades in Amblyopia and Strabismus: The Roles of Sensory Deficits and Nystagmus.
Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To determine how amblyopia subtype, visual acuity, stereoacuity, and nystagmus influence visually guided saccades across viewing conditions in subjects with amblyopia and strabismus. Methods: Visually guided saccades were recorded using video‑oculography in controls, anisometropic amblyopia, strabismic amblyopia, and strabismus without amblyopia subjects under binocular and monocular viewing. Saccadic latency, gain, disconjugacy, movement strategies, and main sequence relationships were quantified. Linear mixed effects models assessed group and viewing condition effects, and χ2 tests compared saccadic strategies and diagnostic distributions by nystagmus status. Results: Saccadic latency varied with viewing condition and was most strongly associated with amblyopic eye visual acuity, with prolonged latencies during amblyopic eye viewing in anisometropic and strabismic amblyopia. Subjects with strabismic amblyopia also showed increased latencies during binocular viewing. Reduced saccadic gain and increased reliance on multiple‑step saccades were most pronounced in strabismic amblyopia and were strongly associated with nystagmus. Saccadic disconjugacy was greatest in subjects with reduced stereoacuity and was most evident during binocular viewing. Main sequence relationships were preserved across all cohorts, including those with nystagmus. Conclusions: Visually guided saccade abnormalities in amblyopia and strabismus reflect distinct contributions of sensory deficits and nystagmus. Although saccadic latency primarily indexes sensory access to the target, reduced gain and altered movement strategies are closely associated with nystagmus. Preservation of main sequence kinematics indicates intact saccadic motor execution. These findings identify nystagmus as an important modifier of saccadic accuracy and underscore the need to account for nystagmus when interpreting oculomotor behavior in amblyopia and strabismus, with relevance to visuomotor tasks such as reading and visual scanning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.