Evidence map›Paper›PMID 42223251›Full record

ArticleBritish journal of haematology2026

Central nervous system involvement and relapse in adult acute lymphoblastic leukaemia-a population-based analysis in 2007-2022.

Erik Boberg, Anna Lübking, Emma Bergfelt Lennmyr, Caroline E Dietrich, Joel Joelsson, Karin E Smedby, Tove Wästerlid, Helene Hallböök

Abstract read
In one paragraph

Article in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Erik Boberg *Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0003-1304-0784
Anna Lübking *Department of Haematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.
Emma Bergfelt LennmyrDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Caroline E DietrichDivision of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Joel JoelssonDivision of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Karin E SmedbyDivision of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Tove WästerlidDivision of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Helene HallböökDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.

Funding

Karolinska Institutet FS-2024:0017Region UppsalaStockholm läns landsting RS 2023-0869
6 · The paper itself

Abstract

Central nervous system (CNS) involvement and relapse remains a clinical challenge in the management of acute lymphoblastic leukaemia (ALL), and studies among adult ALL patients are scarce. We identified all adult ALL patients in Sweden between 2007 and 2022 (n = 838) from the population-based ALL register and evaluated factors associated with CNS involvement and relapse. CNS involvement at diagnosis was detected in 7.8% of patients, more often in patients with T-cell ALL (T-ALL) and with white blood cell (WBC) count >30 × 10

Indexed as

Central Nervous System NeoplasmsPrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentAdultAgedFemaleHumansMaleMiddle AgedRecurrenceRisk FactorsSwedenYoung Adultacute lymphoblastic Leukaemiaadultcentral nervous systempopulation‐basedrelapse

Identifiers

PMID42223251
PMCPMC13462185

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.