Evidence map›Paper›PMID 42223241›Full record

ArticleThe Journal of pathology2026

CLEC14A correlates with neutrophil infiltration in hepatocellular carcinoma and mediates neutrophil recruitment across liver endothelial cells.

Joanne M O'Rourke, Dean Kavanagh, Ayla O'Keeffe, Kylie Savoye, Kaiyi Yang, Daniel A Patten, Catherine E Willoughby, Josep M Llovet, Georgiana Neag, Helen L Reeves and 15 more

Abstract read
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In one paragraph

Article in The Journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Joanne M O'RourkeCentre for Liver and Gastrointestinal Research, Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Dean KavanaghMicrocirculation Research Group, Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Ayla O'KeeffeCentre for Liver and Gastrointestinal Research, Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Kylie SavoyeSchool of Mathematics, University of Birmingham, Birmingham, UK.
Kaiyi YangSchool of Mathematics, University of Birmingham, Birmingham, UK.
Daniel A PattenCentre for Liver and Gastrointestinal Research, Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Catherine E WilloughbyMount Sinai Liver Cancer Program, Division of Liver Diseases, Department of Hematology/Oncology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Josep M LlovetMount Sinai Liver Cancer Program, Division of Liver Diseases, Department of Hematology/Oncology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Georgiana NeagDepartment of Inflammation and Ageing, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Helen L ReevesNewcastle University Translational and Clinical Research Institute, The Medical School, Newcastle-upon-Tyne, UK.
Peter W HewettDepartment of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Neena KaliaMicrocirculation Research Group, Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Tahir ShahLiver Unit, Queen Elizabeth Hospital, Birmingham, UK.
Yuk Ting MaDepartment of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Kelly HunterBirmingham Tissue Analytics, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Joe FlintBirmingham Tissue Analytics, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Jack L McMurrayBirmingham Tissue Analytics, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Owen CainDepartment of Pathology, Queen Elizabeth Hospital Birmingham, Birmingham, UK.
Fabian SpillSchool of Mathematics, University of Birmingham, Birmingham, UK.
Derek A MannNewcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, UK.
Amy J NaylorDepartment of Inflammation and Ageing, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Victoria HeathDepartment of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Christopher J WestonCentre for Liver and Gastrointestinal Research, Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Roy BicknellDepartment of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Shishir ShettyCentre for Liver and Gastrointestinal Research, Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0002-4729-2173

Funding

Cancer Research UKCancer Research UK C18873/A26813Cancer Research UK C53575/A29959Cancer Research UK Accelerator AwardCancer Research UK Awards C18342/A23390Cancer Research UK Newcastle Centre CTRQQR-2021\100003Engineering and Physical Sciences Research Council EP/S02297X/1European Commission 101136622Fondazione AIRCFondazione per la Ricerca sul CancroFundación Científica de la Asociación Española Contra el Cáncer C9380/A26813Generalitat de Catalunya 2021-SGR 01347Newcastle NIHR Biomedical Research Centre NIHR203309NIH HHS R01-CA273932-01NIH HHS RO1DK128289NIH HHS RO1DK56621Samuel Waxman Cancer Research FoundationSpanish National Health InstituteVersus Arthritis 21743Wellcome Trust Translational Development Fund
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally, and cases are predicted to rise dramatically over the next few years. Overcoming the immune microenvironment in HCC remains a challenge, and innate immune populations such as tumour-associated neutrophils can potentially impair the success of immunotherapy. Elucidating the mechanisms of neutrophil recruitment across liver endothelium could lead to new approaches to boost the efficacy of immunotherapy. CLEC14A is an endothelium-specific receptor regulating sprouting angiogenesis, upregulated in low shear environments. We found CLEC14A to be highly expressed in both HCC vessels and on vasculature during acute liver injury, leading us to hypothesise that CLEC14A may regulate neutrophil recruitment to the liver and HCC. We found that CLEC14A positively correlated with a neutrophil signature and infiltration in public datasets and surgically resected tissue from HCC. Spatial transcriptomics (ST) of CLEC14A

Indexed as

Carcinoma, HepatocellularEndothelial CellsLectins, C-TypeLiver NeoplasmsNeutrophil InfiltrationNeutrophilsReceptors, MitogenAnimalsCell Adhesion MoleculesHumansLiverNeovascularization, PathologicTumor MicroenvironmentCell Adhesion MoleculesCLEC14A protein, humanLectins, C-TypeReceptors, MitogenadhesionCLEC14Ahepatocellular carcinomaneutrophiltumour endothelium

Identifiers

PMID42223241
PMCPMC13341266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.