ArticleVirulence2026
Do BKPyV genomic features underlie clinical divergence between kidney and hematopoietic transplant recipients?
Article in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BK polyomavirus (BKPyV) persists in the renourinary tract of most adults and can replicate under immunosuppression. In kidney transplant recipients (KTR), it may cause BKPyV-associated nephropathy (BKPyVAN), while in hematopoietic stem cell transplant recipients (HSCT), it is more often linked to hemorrhagic cystitis (HC). These clinical differences are generally attributed to the type of graft and immunosuppressive regimen. However, viral factors such as genotype or mutations might also influence tissue tropism and pathogenesis. This study aimed to compare the virological features of BKPyV between KTR and HSCT recipients and to explore possible associations with clinical manifestations. This retrospective study included 101 transplanted patients (66 KTR, 35 HSCT) at Amiens-Picardie University Hospital (France) between 2019 and 2023, with at least one episode of BKPyV DNAuria during post-allograft follow-up. Viral genotyping was performed by Sanger sequencing, while NGS (Next-generation Sequencing) provided complete coding genome sequences for 51 patients. Genotype distribution was similar in both groups, with Ib2 as the most frequent subtype. No genotype or mutation was associated with a specific graft type or complication, except for the small t antigen gene, which appeared to be more frequently mutated in KTRs. Viral replication occurred earlier and at higher levels in HSCT patients (mean peak DNAuria: 9.3 log
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