ArticleTechnology in cancer research & treatment
Dose-Gradient Function-Guided Reduction of Radiation-Induced Heart Injury in Left-Sided Breast Cancer Treated With Helical Tomotherapy After Mastectomy.
Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
IntroductionRadiation-induced heart injury (RIHI) remains an important concern in left-sided postmastectomy radiotherapy (PMRT), particularly when internal mammary lymph nodes (IMLNs) are included in the target volume. Helical tomotherapy (HT) provides excellent target conformity for complex targets, but cardiac sparing remains challenging. This study evaluated whether dose-gradient function (DGF)-guided optimization could further reduce cardiac exposure in left-sided breast cancer patients treated with HT after modified radical mastectomy.MethodsTwenty-six female patients with left-sided breast cancer who underwent PMRT were retrospectively included. Initial HT plan was generated and evaluated using DGF, which quantifies dose falloff outside the target volume. The patient with the minimum DGF curve area (
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