Evidence map›Paper›PMID 42223197›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

Genetic deletion of cytoglobin exacerbates cardiac hypertrophy and inhibits cardiac fibroblast activation independent of changes in blood pressure.

Le Gia Cat Pham, Kurrim Gilliard, Frances Jourd'heuil, Sarahann Mistretta, John J Schwarz, Harold A Singer, David Jourd'heuil

Abstract read
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In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Le Gia Cat PhamDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, United States.ORCID 0009-0005-4328-2006
Kurrim GilliardDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, United States.
Frances Jourd'heuilDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, United States.
Sarahann MistrettaDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, United States.
John J SchwarzDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, United States.
Harold A SingerDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, United States.ORCID 0000-0001-8554-3239
David Jourd'heuilDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, United States.ORCID 0000-0002-6555-5061

Funding

Role of cytoglobin in promoting smooth muscle cell survival during maladaptive vascular remodelingR01HL142807 · NHLBI · ALBANY MEDICAL COLLEGE · PI JOURD'HEUIL, DAVID · 2019 to 2021
$1.2M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL142807NHLBI NIH HHS R01 HL142807
6 · The paper itself

Abstract

Hypertension-mediated left ventricular hypertrophy and cardiac fibrosis often precede heart failure. Recent studies indicate that cytoglobin (Cygb), a globin expressed in the vasculature, increases systemic blood pressure. The present work aims to determine the role of Cygb in angiotensin II (Ang II)-induced cardiac hypertrophy and fibrosis in the mouse. Males and females global Cygb knockout

Indexed as

Blood PressureCardiomegalyCytoglobinFibroblastsMyocardiumAngiotensin IIAnimalsCells, CulturedFemaleFibrosisMaleMiceMice, Inbred C57BLMice, KnockoutAngiotensin IICygb protein, mouseCytoglobincardiac fibrosiscardiac hypertrophycytoglobinfibroblastshemoglobins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.