Evidence map›Paper›PMID 42223176›Full record

ReviewAmerican journal of reproductive immunology (New York, N.Y. : 1989)2026

T-Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection.

Barbara L Shacklett, Ramatoulaye H Ouattara, April L Ferre

Abstract readReview
In one paragraph

Review in American journal of reproductive immunology (New York, N.Y. : 1989), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Special Issue on New Horizons in HIV and Reproductive Health Research.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Barbara L ShacklettDepartment of Medical Microbiology and Immunology, University of California, Davis, California, USA.ORCID 0000-0002-7067-732X
Ramatoulaye H OuattaraDepartment of Medical Microbiology and Immunology, University of California, Davis, California, USA.
April L FerreDepartment of Medical Microbiology and Immunology, University of California, Davis, California, USA.ORCID 0009-0003-5963-1309

Funding

Cytomegalovirus (CMV), the gut barrier and immune dysfunction in HIVR01AI155680 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HUNT, PETER W, SHACKLETT, BARBARA L. · 2021 to 2025
$4.1M
James B. Pendleton Charitable TrustNCI NIH HHS P30-CA-093373NIAID NIH HHS R01 AI155680NIH HHS R01-AI-155680NIH HHS R01-AI-155680-05S1NIH HHS R01-DK-108350
6 · The paper itself

Abstract

Worldwide, most HIV infections occur across a mucosal surface during sexual contact, with women accounting for nearly half of reported new HIV infections across the globe in 2024. Most new infections in women and girls are believed to involve transmission across mucosal surfaces of the lower reproductive tract, which includes the vagina and ectocervix. Nevertheless, HIV-susceptible target cells are present in both the lower and upper reproductive tract, as are antigen-specific T-cells. Advances in the field of T-cell biology over the past decades have elucidated the differentiation and trafficking of mucosal T-cells, including tissue-resident populations. In addition, recent studies incorporating advances in tissue sampling, immune cell phenotyping and multi-omics technologies have enhanced our understanding of adaptive immune responses to HIV within the reproductive tract. This review summarizes our current understanding of T-cell biology in the female reproductive tract and its relevance to HIV infection.

Indexed as

Genitalia, FemaleHIV-1HIV InfectionsT-LymphocytesAnimalsFemaleHumansMucous Membranefemale reproductive tractHIVT‐cells

Identifiers

PMID42223176
PMCPMC13334958

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.