Evidence map›Paper›PMID 42223129›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2026

Skeletal muscle carnitine-acylcarnitine translocase deletion reveals vulnerability of oxidative muscle to fatty acid oxidation deficiency.

Filip Jevtovic, Nicholas C Williamson, Andrea S Pereyra, Molly K Alexander, Espen E Spangenburg, Jessica M Ellis

Abstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Filip JevtovicDepartment of Translational Neuroscience, Division of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.ORCID 0000-0002-5486-2736
Nicholas C WilliamsonDepartment of Physiology, East Carolina Diabetes and Obesity Institute, Brody School of Medicine at East Carolina University, Greenville, North Carolina, United States.
Andrea S PereyraDepartment of Physiology, East Carolina Diabetes and Obesity Institute, Brody School of Medicine at East Carolina University, Greenville, North Carolina, United States.ORCID 0000-0001-7596-2421
Molly K AlexanderDepartment of Translational Neuroscience, Division of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.
Espen E SpangenburgDepartment of Physiology, East Carolina Diabetes and Obesity Institute, Brody School of Medicine at East Carolina University, Greenville, North Carolina, United States.ORCID 0000-0001-8339-1972
Jessica M EllisDepartment of Translational Neuroscience, Division of Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.ORCID 0000-0003-3803-8461

Funding

Determining the Biological Effects of Mitochondrial Acyl ToxicityR01DK125812 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ELLIS, JESSICA M · 2020 to 2025
$2.3M
Walk this way: leveraging of a unique skeletal muscle that is resistant to ischemic injuryR33AR078100 · NIAMS · EAST CAROLINA UNIVERSITY · PI SPANGENBURG, ESPEN E · 2023 to 2023
$378k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 7R01DK125812-06NIAMS NIH HHS R33 AR078100NIDDK NIH HHS R01 DK125812
6 · The paper itself

Abstract

Fatty acid oxidation (FAO) is a critical bioenergetic source for skeletal muscle, with FAO impairments being linked to metabolic and contractile dysfunction. FAO is regulated by the carnitine shuttle, in which FAO-eligible fatty acids, in the form of acylcarnitines, are transported into the mitochondrial matrix by carnitine-acylcarnitine translocase (CACT); however, the role of CACT in muscle in vivo has remained unexplored. To determine the requirement of CACT in muscle FAO and its influence on muscle mitochondrial bioenergetics, lipid profile, and muscle contractility, a novel conditional skeletal muscle-specific CACT knockout mouse (

Indexed as

Carnitine AcyltransferasesFatty AcidsMuscle, SkeletalAnimalsCarnitineEnergy MetabolismLipid MetabolismMiceMice, KnockoutMitochondria, MuscleMuscle ContractionOxidation-ReductionCarnitineCarnitine AcyltransferasesFatty Acidscarnitine-acylcarnitine translocasefatty acid metabolismmuscle contractionskeletal muscle

Identifiers

PMID42223129
PMCPMC13501528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.