Evidence map›Paper›PMID 42223042›Full record

ArticleAllergy, asthma & immunology research2026

Serum Neuropeptides in Chronic Spontaneous Urticaria: Associations With Disease Activity and Clinical Phenotypes.

Zhenrui Shi, Xinyi Deng, Jieru Ren, Siyao Lu, Guozhen Tan

Abstract read
In one paragraph

Article in Allergy, asthma & immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhenrui Shi *Department of Dermatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0001-9416-1152
Xinyi Deng *Department of Dermatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0009-0003-4241-9598
Jieru RenDepartment of Dermatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-6698-9005
Siyao LuDepartment of Dermatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-9176-2486
Guozhen TanDepartment of Dermatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. tangzh@mail.sysu.edu.cn.ORCID https://orcid.org/0009-0004-8984-7685

Funding

Guangdong Basic and Applied Basic Research Foundation 2022A1515012020National Natural Science Foundation of China 82203906
6 · The paper itself

Abstract

Neuropeptides have been implicated in chronic spontaneous urticaria (CSU), but clinical data remain limited. We measured serum calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), and stem cell factor by enzyme-linked immunosorbent assay in 80 patients with CSU and 40 age- and sex-matched healthy controls. CSU patients were categorized as flare or non-flare at sampling according to the presence or absence of wheals on the day of blood collection, and disease activity was assessed using the Urticaria Activity Score and its 7-day version (UAS7). Median serum CGRP levels were significantly higher in CSU patients than in healthy controls (263.86 pg/mL

Indexed as

biomarker, urticaria activity score, enzyme-linked immunosorbent assayChronic spontaneous urticarianeuropeptide

Identifiers

PMID42223042
PMCPMC13226869

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.