ArticleAllergy, asthma & immunology research2026
Targeting CD30L Alleviates Airway Remodeling via JNK/p38 MAPK Pathway in OVA-Induced Asthmatic Mice.
Changjuan Xu, Xiaofei Liu, Rong Zeng, Jintao Zhang, Yun Pan, Chenxiao Qiao, Pengfei Wang, Shuochuan Shi, Ying Wang, Xuemin Liu and 6 more
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In one paragraphArticle in Allergy, asthma & immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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16 authors.
Changjuan XuDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0000-0001-8414-2986 Xiaofei LiuDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0000-0002-7285-7578 Rong ZengDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0000-0003-1320-8815 Jintao ZhangDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0000-0002-1309-6836 Yun PanDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0000-0002-5014-0322 Chenxiao QiaoDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0000-0003-1421-1143 Pengfei WangDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0000-0002-7381-5767 Shuochuan ShiDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0009-0000-4648-4125 Ying WangDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0009-0006-6200-4279 Xuemin LiuDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0009-0000-4777-7093 Qian QiDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0000-0002-5813-3194 Mingxia GaoDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0000-0001-7546-5863 Lili ZhiDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0000-0001-5664-9974 Xueli DongDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China.ORCID https://orcid.org/0009-0000-5698-1758 Liang DongDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, China. dl5506@126.com.ORCID https://orcid.org/0000-0001-7707-9982 Funding
China International Medical Foundation Z-2014-08-2309-1China International Medical Foundation Z-2017-24-2301Jinan Clinical Medicine Research Program for Respiratory Disease 202132002Key Research and Development Program of Shandong Province 2021SFGC0504National Natural Science Foundation of China 82270032National Natural Science Foundation of China 82470028Natural Science Foundation of Shandong Province ZR2024MH153Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0529700Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0529704Shandong Provincial Natural Science Foundation ZR2021LSW015
6 · The paper itselfAbstract
purposeAirway remodeling is a key pathological feature of asthma. The CD30 ligand (CD30L), a member of the tumor necrosis factor (TNF) superfamily encoded by the
methodsWe investigated CD30L expression and localization in lung specimens from asthma patients and ovalbumin (OVA)-induced asthmatic mice. Subsequently, we established asthmatic mice with macrophage-specific
resultsCD30L expression was upregulated in asthmatic lung tissues (human/mice) and colocalized with macrophage markers.
conclusionsCollectively, these findings demonstrate that CD30L critically regulates asthma airway remodeling via the JNK/p38 MAPK pathway, strongly suggesting its therapeutic potential as a target for airway remodeling in asthma.
Indexed as
Airway remodelingasthmaCD30 ligandepithelial-mesenchymal transition (EMT)extracellular matrix (ECM)macrophagesMAPK signaling systemovalbuminpathology
Identifiers
PMID42223038
PMCPMC13226872
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