ArticleACS omega2026
Injectable Silk Fibroin-Puerarin Hydrogels with Tunable Supramolecular Organization as a Potential Platform for Tissue Engineering.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Injectable supramolecular hydrogels represent an emerging class of biomaterials with significant potential for minimally invasive tissue engineering and drug delivery applications. In this study, the effects of varying puerarin (PUE, 1-5%) contents, a bioactive isoflavonoid capable of gelation, on the physicochemical and in vitro biological properties of silk fibroin (SF) were systematically evaluated. Hydrogel formation was driven by hydrogen-bonding interactions between SF and PUE, as confirmed by FTIR analysis, without altering the crystalline structure of SF, as evidenced by X-ray diffraction. Microstructural analysis by scanning electron microscopy (SEM) revealed that increasing PUE content progressively reduced pore size and generated a denser polymeric network, resulting in a decrease in swelling capacity. Thermal analyses (TGA/DSC) demonstrated the combined thermal stability and degradation behavior of the resulting system. Rheological characterization showed a marked increase in viscosity and a predominance of storage modulus (
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