Evidence map›Paper›PMID 42222815›Full record

ArticleACS omega2026

Helix-Aggregation Interplay in Nucleophosmin 1: Structural, Morphological, and Cytotoxic Consequences of Fragment Length.

Daniele Florio, Ilaria Leone, Sara La Manna, Alessia Cugudda, Flavia Anna Mercurio, Marilisa Leone, Daniela Marasco

Abstract read
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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniele FlorioIRCCS SYNLAB SDN, via G. Ferraris 144, 80146 Naples, Italy.
Ilaria LeoneIRCCS SYNLAB SDN, via G. Ferraris 144, 80146 Naples, Italy.
Sara La MannaDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
Alessia CuguddaDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
Flavia Anna MercurioInstitute of Biostructures and Bioimaging (IBB), CNR, Via P. Castellino 111, 80131 Naples, Italy.
Marilisa LeoneInstitute of Biostructures and Bioimaging (IBB), CNR, Via P. Castellino 111, 80131 Naples, Italy.ORCID https://orcid.org/0000-0002-3811-6960
Daniela MarascoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.ORCID https://orcid.org/0000-0002-6618-2949

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleophosmin 1 (NPM1) undergoes liquid-liquid phase separation (LLPS) and can form amyloid-like aggregates when structural elements within its C-terminal domain become destabilized. The helical region spanning residues 264-277 represents a key amyloidogenic segment, and its conformational balance is involved in NPM1 misfolding in acute myeloid leukemia (AML). Here, we examined how N- and C-terminal sequence extensions modulate the structural and aggregative behavior of two C-terminal fragments, NPM1

Identifiers

PMID42222815
PMCPMC13216914

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.