ArticleACS omega2026
Bridging Manual and Computational Approaches: The Pseudophosphatase Scanner for Genome-Wide Fungal Pseudophosphatome Analysis.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Pseudophosphatases are proteins with mutations in their catalytic motifs, resulting in the predicted loss of enzymatic activity. Although pseudophosphatases are established regulators of various signaling pathways in humans and other metazoans, their biological roles in fungi remain largely unexplored. Identifying fungal-specific pseudophosphatases is particularly important because they control fungal growth, development, and virulence through noncatalytic mechanisms and could represent selective antifungal targets due to the absence of close human homologues. Here, we present a comprehensive overview of fungal pseudophosphatases identified across all major phosphatase families. To compile a robust data set, we integrated information from literature and databases as well as systematically scanned the phosphatomes of the human pathogenic yeast
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