Evidence map›Paper›PMID 42222805›Full record

ArticleACS omega2026

Leveraging Neural Networks to Correct FoldX Free Energy Estimates.

Jonathan E Barnes, L América Chi, Shubham Kumar Pandey, F Marty Ytreberg, Jagdish Suresh Patel

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jonathan E BarnesInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho 83844, United States.ORCID https://orcid.org/0000-0002-5434-1391
L América ChiInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho 83844, United States.ORCID https://orcid.org/0000-0002-2606-0357
Shubham Kumar PandeyDepartment of Chemical and Biological Engineering, University of Idaho, Moscow, Idaho 83844, United States.ORCID https://orcid.org/0000-0001-6138-0738
F Marty YtrebergInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho 83844, United States.ORCID https://orcid.org/0000-0001-7439-8224
Jagdish Suresh PatelInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho 83844, United States.ORCID https://orcid.org/0000-0003-4999-5347

Funding

Sequence-structure-function relationships in human visual photopigmentsP20GM104420 · NIGMS · UNIVERSITY OF IDAHO · PI MILLER, CRAIG R · 2015 to 2024
$22.9M
NIGMS NIH HHS P20 GM104420
6 · The paper itself

Abstract

Fast and accurate prediction of folding stability and binding affinity due to protein mutations is a critical need in structural biology. While experimental methods are accurate, they are often time-consuming and costly. Computational approaches like FoldX offer fast and inexpensive alternatives by estimating free energy changes (ΔΔ

Identifiers

PMID42222805
PMCPMC13216946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.