ArticleACS omega2026
Effects of Polyethylene Glycol on the Hydrogen Bonds and Stacking Interactions of DNA/DNA, DNA/RNA, and RNA/RNA Calculated by a Mesoscopic Model.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The addition of polyethylene glycol (PEG) to the buffer of oligonucleotide melting experiments is a way to simulate the cellular crowding. PEG reduces the water activity, but how this affects the hydrogen bonding and base stacking is mostly unknown. Here, we use published melting temperature data for DNA/DNA (DD), DNA/RNA (DR), and RNA/RNA (RR) to calculate how the hydrogen bonds and stacking interactions change upon the addition of PEG. For this, we used a mesoscopic model that describes the helical stability in terms of the intramolecular interactions. For the hydrogen bonds, we find that PEG has almost no effect on DD and a moderate effect on CG in DR. However, for RR, hydrogen bonds become much stronger for CG but much weaker for AU. Changes in stacking interactions were also found to be strongest for RR.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.