Evidence map›Paper›PMID 42222614›Full record

ArticleACG case reports journal2026

An Indolent Enteropathy Accelerated by Combination Immune Checkpoint Inhibitor Therapy.

Noah Lybik, Benjamin D Liu, Joseph R Fuchs, Jacob S Choi, Chengwei Peng, Jennifer L Rytych, Saad Saffo

Abstract readCase Reports
In one paragraph

Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Noah LybikDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Benjamin D LiuDivision of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Joseph R FuchsDivision of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Jacob S ChoiDivision of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Chengwei PengDivision of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Jennifer L RytychDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Saad SaffoDivision of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID https://orcid.org/0000-0001-5375-3100

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of immunotherapy has dramatically altered the landscape of cancer treatment, leading to improved clinical outcomes for several malignancies. However, gastrointestinal immune-related adverse events are commonly encountered, and among patients with underlying autoimmune disorders, the risks and sequelae of such events may be more significant. Here, we present the case of a 76-year-old woman who developed isolated enteritis with diffuse ulceration shortly after the initiation of ipilimumab and nivolumab and ultimately passed away from refractory gastrointestinal bleeding. The clinical, endoscopic, and histologic findings were suggestive of a preexisting enteropathy that was rapidly accelerated by immune checkpoint inhibitor exposure.

Indexed as

enteropathygastrointestinal bleedinggastrointestinal immune-related adverse eventsimmune checkpoint inhibitorsolmesartan

Identifiers

PMID42222614
PMCPMC13218753

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.