ArticleFrontiers in genetics2026
m5C and m6A cooperatively stabilize EPHB4 to drive lymphatic metastasis in gastric cancer.
Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Gastric cancer remains a major cause of cancer-related mortality worldwide, and lymph node metastasis is a major determinant of recurrence and poor prognosis. However, the molecular basis of lymphatic dissemination, particularly the epitranscriptomic regulation of metastasis-related genes, remains unclear. We investigated whether RNA modifications promote gastric cancer lymphatic metastasis by regulating EPHB4, a receptor tyrosine kinase implicated in lymphangiogenesis and nodal spread. Methods: We integrated transcriptome sequencing of gastric cancer tissues, bioinformatic database analyses, and immunohistochemical validation to identify EPHB4 as a metastasis-associated gene. Results: Transcriptome sequencing identified EPHB4 as significantly upregulated in lymph node-positive gastric cancer. Database analyses and immunohistochemistry further supported the association of high EPHB4 expression with poor clinical outcome. Functionally, EPHB4 promoted lymphatic metastasis Conclusion: These findings reveal a cooperative epitranscriptomic mechanism in which NSUN2/YBX1-mediated m
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