Evidence map›Paper›PMID 42222592›Full record

ArticleThe journal of allergy and clinical immunology. Global2026

The Michigan Sibling Immunity Birth Study (M-SIBS): Study design protocol for a unique food allergy birth cohort.

Kelly M O'Shea, Elizabeth Brooks, Nancy Polmear-Swendris, Ian F Slack, Jennifer A Smith, Aubree Gordon, Danica M Aquino, James E Gern, Gurjit K Khurana Hershey, Christine C Johnson and 5 more

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In one paragraph

Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kelly M O'SheaMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich.
Elizabeth BrooksMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich.
Nancy Polmear-SwendrisMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich.
Ian F SlackMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Mich.
Aubree GordonDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Mich.
Danica M AquinoDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Mich.
James E GernDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
Gurjit K Khurana HersheyDepartment of Pediatrics, University of Cincinnati, Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Christine C JohnsonDepartment of Public Health Sciences, Henry Ford Health Systems, Detroit, Mich.
Jodi WilkowskiMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich.
Judy HinesMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich.
Nick W LukacsMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich.
Charles F SchulerMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich.
James R BakerMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, Mich.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Food allergy is a rapidly escalating public health concern, yet the biologic pathways that link early-life exposures with disease onset remain poorly defined. No existing food-allergy birth cohort has yet paired criterion-standard oral food challenges with comprehensive, family-wide multiomics profiling. Objective: The Michigan Sibling Immunity Birth Study (M-SIBS) was established to elucidate early-life genetic and environmental interactions that drive disease. By enrolling entire families, including atopic siblings, the study leverages shared genetics, perinatal sampling, and household exposures to identify modifiable factors in food allergy development. Methods: M-SIBS is a prospective birth cohort at the University of Michigan that will enroll 1000 infants who have a first-degree relative with atopic disease. Mothers are recruited prenatally along with biologic fathers and siblings. Infants are then followed through 36 months of life. Extensive longitudinal phenotyping includes (1) serial skin prick and serum-specific IgE testing to the 9 most common food allergens at designated intervals; (2) standardized oral food challenges to confirm any positive result; (3) biospecimen collection at specified time points prebirth and postbirth; and (3) validated clinical, psychosocial, and environmental surveys administered longitudinally. It is designed to integrate genomic, epigenomic, transcriptomic, metabolomics, and microbiome data into a single multiomics framework across the family unit. Conclusions: M-SIBS integrates criterion-standard clinical diagnostics for food allergy with family-based multiomics to generate an unprecedented data set on the earliest drivers of food allergy.

Indexed as

biospecimen collectionbirth cohortearly-life exposuresFood allergygene-environment interactionmultiomicsoral food challengeplacentasibling

Identifiers

PMID42222592
PMCPMC13217597

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.